Charred onions with balsamic, walnuts and ricotta,Brush sweet onions in a balsamic honey glaze, bake until tender and serve with dollops of creamy ricotta for an easy veggie side for 4-6 people Tags:entertainolivemagazine.comrecipesVegetarian
How to get the best home equity loan,In order to get the best home equity loan for their needs homeowners should first do these three things. Tags:cbsnews.commoneywatch managing your money
The biggest flaw in Trump’s offensive against his former fixer,In the hopes of discrediting Michael Cohen, Donald Trump is effectively arguing, “Don’t trust the guy who committed crimes for me!” Tags:MSNBCmsnbc.com
Biggest Twist in Bigg Boss 11: Here's How The Elimination Will Happen This Week,Well, let us tell you this year the controversial reality show is giving the audience a chance to save their favourite contestant with LIVE and in-person voting. Tags:bigg boss 11hina khanLuv TyagiMoviesNews18news18.comShilpa ShindeVikas Gupta
Structural and mechanistic insights into fungal 尾-1,3-glucan synthase FKS1,The membrane-integrated synthase FKS is involved in the biosynthesis of β-1,3-glucan, the core component of the fungal cell wall1,2. FKS is the target of widely prescribed antifungal drugs, including echinocandin and ibrexafungerp3,4. Unfortunately, the mechanism of action of FKS remains enigmatic and this has hampered development of more effective medicines targeting the enzyme. Here we present the cryo-electron microscopy structures of Saccharomyces cerevisiae FKS1 and the echinocandin-resistant mutant FKS1(S643P). These structures reveal the active site of the enzyme at the membrane–cytoplasm interface and a glucan translocation path spanning the membrane bilayer. Multiple bound lipids and notable membrane distortions are observed in the FKS1 structures, suggesting active FKS1–membrane interactions. Echinocandin-resistant mutations are clustered at a region near TM5–6 and TM8 of FKS1. The structure of FKS1(S643P) reveals altered lipid arrangements in this region, suggesting a drug-resistant mechanism of the mutant enzyme. The structures, the catalytic mechanism and the molecular insights into drug-resistant mutations of FKS1 revealed in this study advance the mechanistic understanding of fungal β-1,3-glucan biosynthesis and establish a foundation for developing new antifungal drugs by targeting FKS. Using cryo-electron microscopy, the molecular architecture and catalytic mechanism of action of the fungal β-1,3-glucan synthase FKS1 are determined. Tags:chaiChangdongCryoelectron microscopyFungiglycobiologyHuHuanhuanhumanities and social sciencesJiaLiumultidisciplinaryNaturenature.compingscienceSunXinlinYang
Sharon Stone Breaks Her Silence On The Death Of Her Brother Patrick In Tearful Video,Actress Sharon Stone is grieving the death of her brother, Patrick Joseph Stone, in a highly emotional video clip. Tags:Newssharon stoneSmart NewsstarsThe Blasttheblast.comTop stories
Three Pioneering Scholars Who Died This Year,They believed that the stories of marginalized communities were worth chronicling Tags:Smart Newssmithsonianmag.com
Our Ancestors Ate a Paleo Diet, With Carbs,Our Ancestors Ate a Paleo Diet, With Carbs,A modern hunter-gatherer group known as the Hadza has taught researchers surprising things about the highly variable menu consumed by humans past Tags:popularsciencesmithsonianmag.com
Meet Ai-Da, the First Robot to Speak Before U.K. Parliament,Meet Ai-Da, the First Robot to Speak Before U.K. Parliament,The robot answered questions about technology, art and consciousness Tags:lifestyleSmart Newssmithsonianmag.com
Meet the First Black Woman Puppeteer on 'Sesame Street',Meet the First Black Woman Puppeteer on 'Sesame Street',Megan Piphus Peace, 29, plays a 6-year-old Black girl named Gabrielle Tags:FeaturedlifestyleSmart Newssmithsonianmag.com
Original 'E.T.' Mechatronic Model Could Fetch $3 Million at Auction,Original 'E.T.' Mechatronic Model Could Fetch $3 Million at Auction,The metallic skeleton, created by special effects pro Carlo Rambaldi in 1981, features 85 movement points Tags:FeaturedlifestyleSmart Newssmithsonianmag.com
Ancient Maya Cities Were Polluted With High Levels of Mercury,Ancient Maya Cities Were Polluted With High Levels of Mercury,The concentrations at some dig sites could be hazardous for today's archaeologists Tags:lifestyleSmart Newssmithsonianmag.comTrending
This 18-Year-Old Recreated the ‘Entire Universe’ in Minecraft,This 18-Year-Old Recreated the ‘Entire Universe’ in Minecraft,From the video game's blocks, he built galaxies, a nebula, a black hole and the solar system Tags:lifestyleSmart Newssmithsonianmag.com
Meet the Rare Gender-Neutral Kitten With No Sex Organs,Meet the Rare Gender-Neutral Kitten With No Sex Organs,The formerly homeless cat has now been adopted in the U.K. Tags:FeaturedlifestyleSmart Newssmithsonianmag.com
A Small Town in Alaska Is Home to the World's First Hammer Museum,A Small Town in Alaska Is Home to the World's First Hammer Museum,Perhaps no one knows the history of the tool better than collector Dave Pahl, who opened a shrine of his artifacts in Haines 20 years ago Tags:lifestylesmithsonianmag.comTravel
Three ways moving on from Aaron Rodgers impacts Packers
Three ways moving on from Aaron Rodgers impacts Packers,Moving on from a franchise quarterback is a challenging situation for any NFL team. Here are three ways the Packers will be impacted if Rodgers has indeed played his last game as a member of the
DOH warns vs eating seafood from oil spill areas
DOH warns vs eating seafood from oil spill areas,The Department of Health warned the public yesterday against eating fish and other seafood from areas affected by the oil spill.
The post DOH warns vs eating seafood from oil spill areas appeared first
Washington turns to Wall Street to help rescue dying bank
Washington turns to Wall Street to help rescue dying bank,In a scene reminiscent of the last financial crisis, the federal government turned to Wall Street this week for help with a blossoming emergency in the banking sector
Lucy in the sky, with diamond-like stars,One space mission I am avidly keeping track of is Lucy, which launched last October. It’s headed out to Jupiter’s orbit — not Jupiter itself, but its orbit — to pass by quite a few asteroids that share their path with the giant planet. In one sense it’s the most ambitious asteroid mission ever created: It will take close-up images of at least seven asteroids! Tags:AsteroidsBad AstronomyFeaturesjupiterlucyScienceSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIREtrojans
'Severance' Season 1 may be done, but we still have questions,We don't have an actual timeline as far an air date goes, but from a need-it-now perspective, it's going to be a long, long wait until Season 2 of Severance hits our screens. Until then the Apple TV+ show has given fans lots of food for thought with each new episode of the sci-fi thriller that's been released. Tags:Apple TV+Ben StillerNewsOpinionSeveranceSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIREtv
The best comics of March 2022: Captain Carter, a Batman/Superman team-up, new X-Men & more,Spring is here, and we've got plenty of good comics to go along with it. March brought several exciting new series from the Big Two and beyond this year, including a new Batman/Superman team-up book from an all-star creative team, a What If...? story given the expanded treatment, a new Mike Mignola sci-fi adventure, and more. Tags:comicsDark Horse Comicsdc comicsImage ComicsListsMarvel ComicsNewsSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIRE
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