Drug triggers immune cells to attack prostate cancer,A single drug compound simultaneously attacks hard-to-treat prostate cancer on several fronts, according to a new study in mice and human cells. It triggers immune cells to attack, helps the immune cells penetrate the tumor, and cuts off the tumor's ability to burn testosterone as fuel, according to new research from Washington University School of Medicine in St. Louis. The drug may offer a promising new strategy for treating patients whose tumors don't respond to standard therapy.
Drug triggers immune cells to attack prostate cancer
A single drug compound simultaneously attacks hard-to-treat prostate cancer on several fronts, according to a new study in mice and human cells. It triggers immune cells to attack, helps the immune cells penetrate the tumor, and cuts off the tumor’s ability to burn testosterone as fuel, according to new research from Washington University School of Medicine in St. Louis. The drug may offer a promising new strategy for treating patients whose tumors don’t respond to standard therapy.
How to Clean and Care for a Leather Purse,Maintaining a leather handbag requires proper care. Learn how to correctly remove dirt and stains from faux and authentic leather purses. Tags:Cleaning & OrganizingFabric Carelaundrythespruce.com
Foreclosed Review - Techraptor,Foreclosed feels like an Xbox Live Arcade game from 2008, or perhaps a forgotten PlayStation 2 title from 2004, and not in a good way. It's a very rudimentary experience; nothing here feels fleshed-out or innovative. It's got third-person shooting, light RPG elements, and occasional forced stealth sections, and none of them feel up to scratch in 2021. If you're desperate for a derivative sub-Max Payne shooter with none of that franchise's zinging wit and kinetic motion, Foreclosed will probably suffice, but it's really not an essential title for anyone. Tags:ForeclosedGamesPCReviewtechraptor.net
How to Clean Wicker Baskets in 3 Easy Steps,Wicker is a lightweight but durable woven material used for baskets, furniture, and accessories. Learn how to clean natural and synthetic wicker baskets. Tags:CleaningCleaning & OrganizingCleaning How Tosthespruce.com
Model provides insight into how autism arises,The development of autism may now become easier to understand, thanks to an explanatory model presented in a thesis from University of Gothenburg. This model provides new insights into how various risk factors give rise to autism and why there is such great variability between individuals. Tags:genomeweb.com
Hospitals bound to patient safety rules that aren't all backed by evidence,If health care facilities such as hospitals and nursing homes don't follow patient safety rules set by The Joint Commission (TJC)—the independent organization responsible for accrediting health care facilities—they may lose their accreditation, and consequently, lose patients and millions of dollars every year in funding. Tags:genomeweb.compodcastsThe Science
Fruit flies could help unlock diets to treat rare disease, study finds,International researchers led by Monash University biologists have identified a new way to explore how changing diets may help alleviate disease symptoms—particularly for individuals with disorders that affect how protein is metabolized. Tags:genomeweb.com
Study finds picky eaters are put off by food depending on plateware color,Academics have examined the effect of color among picky and non-picky eaters, in a first-of-its-kind study. Tags:genomeweb.com
Study Uncovers Potential New Drug Targets for Liver Fibrosis,A team reports in Science Translational Medicine that inhibiting a receptor-ligand pair could reduce advanced fibrosis in a mouse model of nonalcoholic steatohepatitis. Tags:Filed underGene Expression and RNA Sequencinggenomeweb.comIn The Journals
Cardiomyopathy Risk Increased in Individuals With Atrial Fibrillation History, TTN Variants,With data for roughly 450,000, researchers at Genetics in Medicine saw a pronounced jump in cardiomyopathy risk in individuals with both risky TTN variants and an early history of atrial fibrillation. Tags:cardiovascular diseaseFiled undergenomeweb.comIn The Journals
Researchers discover existing drug can disrupt coronavirus replication,In early 2020, Eric Pringle and Brett Duguay found themselves spending much of their time in their microbiology lab on the seventh floor of Dal's Tupper Building. The virologists were busy testing potential antivirals for common cold coronaviruses and were seeing promising results. Tags:genomeweb.com
Statistics framework to remove bias from debate about how well mouse models mimic human disease,Mice and other animals have been key to some of the biggest medical breakthroughs in human history. But animals aren't always good models of human disease, leading to failed experiments and controversy over their usefulness. Tags:genomeweb.com
Calorie restriction slows pace of aging in healthy adults,In a first of its kind randomized controlled trial an international team of researchers led by the Butler Columbia Aging Center at the Columbia University Mailman School of Public Health shows that caloric restriction can slow the pace of aging in healthy adults. The CALERIE intervention slowed pace of aging measured from participants' blood DNA methylation using the algorithm DunedinPACE (Pace of Aging, Computed from the Epigenome). The intervention effect on DunedinPACE represented a 2-3 percent slowing in the pace of aging, which in other studies translates to a 10-15 percent reduction in mortality risk, an effect similar to a smoking cessation intervention. The results are published online in the journal Nature Aging. Tags:genomeweb.com
Access matters: Lack of resources is associated with increased mortality in childhood cancer survivors,St. Jude Children's Research Hospital scientists have found that socioeconomic deprivation, the presence of treatable chronic health conditions and frailty are independently associated with increased late mortality in childhood cancer survivors. The work utilized the well-characterized group of survivors, the St. Jude lifetime cohort study (St. Jude LIFE). Tags:genomeweb.com
'Mass testing' linked to 25% cut in COVID-19 related hospital admissions,The first ever voluntary "mass testing" pilot for people without COVID symptoms was associated with an overall 25% reduction in COVID-19 related hospital admissions, including an initial 43% reduction with military assistance, finds a study published by The BMJ today. Tags:genomeweb.com
Protection against allergic asthma: When innate lymphoid cells educate alveolar macrophages,A study conducted by researchers at the University of Liège on group 2 innate lymphoid cells (or ILC2s) shows that the functional reprogramming of these cells following their exposure to viruses allows our body to react differently to exposure to certain respiratory allergens. This study is published in Science Immunology. Tags:genomeweb.com
Epigenetic Analysis Suggests Pregnancy Complications Impact Biological Maturity at Birth,With DNA methylation-based clock algorithms, researchers see reduced maturity in female babies born to mothers with preeclampsia or gestational diabetes. Tags:Epigenomics and Epigenetics ResearchFiled undergenomeweb.comIn The Journals
Machine learning model focuses on news articles to predict food crisis outbreaks,A team of researchers has developed a machine learning model that draws from the contents of news articles to effectively predict locations that face risks of food insecurity. The model, which could be used to help prioritize the allocation of emergency food assistance across vulnerable regions, marks an improvement over existing measurements. Tags:genomeweb.com
Latent HIV Found in White Blood Cells of Individuals on Long-Term Treatments,Researchers in Nature Microbiology find HIV genetic material in monocyte white blood cells and in macrophages that differentiated from them in individuals on HIV-suppressive treatment. Tags:Filed undergenomeweb.comIn The Journalsinfectious disease
Ketamine found to increase brain noise,An international team of researchers including Sofya Kulikova, Senior Research Fellow at the HSE University-Perm, found that ketamine, being an NMDA receptor inhibitor, increases the brain's background noise, causing higher entropy of incoming sensory signals and disrupting their transmission between the thalamus and the cortex. This finding may contribute to a better understanding of the causes of psychosis in schizophrenia. An article with the study's findings has been published in the European Journal of Neuroscience. Tags:genomeweb.com
Genetic discovery could lead to early detection, treatment for osteoarthritis,Genetic discovery could lead to early detection, treatment for osteoarthritis,A newly detected flaw in a genetic signaling pathway that leads to a hyper-active inflammatory response could help explain why some people are more prone to develop severe osteoarthritis than others, according to University of Utah Health scientists. They say the discovery could eventually lead to ways of detecting early onset of the disease—even before symptoms occur—and the development of new treatments for it. Tags:genomeweb.comscienceTrending
Study highlights extent of moral injuries faced by health care workers during pandemic,Staff across all levels of U.K. health and social care reported feeling betrayed, morally violated and being treated unjustly and unfairly at work during the COVID-19 pandemic, a study led by the University of Liverpool has found. Tags:genomeweb.compopularThe Science
Gene that guides earliest social behaviors could be key to understanding autism,Little is known about how social behavior develops in the earliest stages of life. But most animals––including humans––are born with an innate ability to interact socially or form bonds with others. And that contributes to success throughout life. Tags:genomeweb.com
PLOS Papers on Leukemic Febrile Neutropenia Microbes, Keloid Disorder, Leishmania Parasites in Brazil,In PLOS this week: using metagenomic shotgun sequencing to diagnose microbial infections, and more. Tags:Filed underGenetic researchgenomeweb.comIn The JournalsThe Science
How to Get Claire Redfield in Fortnite
How to Get Claire Redfield in Fortnite,With the Resident Evil 4 remake just days away, players can now play as Claire Redfield in Fortnite. Fortnite x Resident Evil marks the first collaboration in
U.N. hopes water meeting can create 'rippling effect' to stave off crisis
U.N. hopes water meeting can create 'rippling effect' to stave off crisis,There is no international binding agreement for water like the one reached for climate in Paris in 2015, or framework like that established to protect nature in Montr
Black Equestrians Want to Be Safe. But They Can’t Find Helmets.
Black Equestrians Want to Be Safe. But They Can't Find Helmets.,Chanel Robbins has been riding horses most of her life, ever since her grandmother traded a cow from their family’s farm in Ontario for a pony when she was 7.
The post Black Equest
15 Ways To Revive Your Dry Nails And Cuticles – Glam
15 Ways To Revive Your Dry Nails And Cuticles - Glam,Do you have dry nails and cuticles? While your first instinct may be to run to the nearest nail salon, you can revive them at home. Here's how.
Watch Kenan Thompson play a fictional sci-fi author on 'Late Night with Seth Meyers',This year, Kenan Thompson celebrates his 20th anniversary on Saturday Night Live, and in that time he's played many, many characters. Throughout his record-setting run on the show, Thompson has proven himself a reliable source of steady laughter even in sketches that aren't working, in part because he can slip easily into a persona and just milk it for all it's worth. Tags:Kenan ThompsonLate Night With Seth MeyersNewssaturday night liveSeth MeyersSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIREtv
Alan Tudyk gives an alien hand thumbs up from set of SYFY’s ‘Resident Alien’ Season 3,Just in case you were wondering how things were going on the set of Resident Alien Season 3, we've got some proof that the latest installment of the SYFY series is coming along just fine. Some of the cast members of the sci-fi mystery show have been posting updates and they seem to be having a great time. Tags:Alan TudykLinda HamiltonNewsResident AlienSara TomkoSYFY Official SiteSYFY SeriesSYFY WIRE Blog Postsyfy.comSYFYWIREtv
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