'Not the time': Perrottet's warning as Teal threat looms,Less than three weeks out from the NSW election, Premier Dominic Perrottet is urging voters to reject independent candidates.
'Not the time': Perrottet's warning as Teal threat looms
Less than three weeks out from the NSW election, Premier Dominic Perrottet is urging voters to reject independent candidates.
Charred onions with balsamic, walnuts and ricotta,Brush sweet onions in a balsamic honey glaze, bake until tender and serve with dollops of creamy ricotta for an easy veggie side for 4-6 people Tags:entertainolivemagazine.comrecipesVegetarian
How to get the best home equity loan,In order to get the best home equity loan for their needs homeowners should first do these three things. Tags:cbsnews.commoneywatch managing your money
The biggest flaw in Trump’s offensive against his former fixer,In the hopes of discrediting Michael Cohen, Donald Trump is effectively arguing, “Don’t trust the guy who committed crimes for me!” Tags:MSNBCmsnbc.com
Biggest Twist in Bigg Boss 11: Here's How The Elimination Will Happen This Week,Well, let us tell you this year the controversial reality show is giving the audience a chance to save their favourite contestant with LIVE and in-person voting. Tags:bigg boss 11hina khanLuv TyagiMoviesNews18news18.comShilpa ShindeVikas Gupta
Structural and mechanistic insights into fungal 尾-1,3-glucan synthase FKS1,The membrane-integrated synthase FKS is involved in the biosynthesis of β-1,3-glucan, the core component of the fungal cell wall1,2. FKS is the target of widely prescribed antifungal drugs, including echinocandin and ibrexafungerp3,4. Unfortunately, the mechanism of action of FKS remains enigmatic and this has hampered development of more effective medicines targeting the enzyme. Here we present the cryo-electron microscopy structures of Saccharomyces cerevisiae FKS1 and the echinocandin-resistant mutant FKS1(S643P). These structures reveal the active site of the enzyme at the membrane–cytoplasm interface and a glucan translocation path spanning the membrane bilayer. Multiple bound lipids and notable membrane distortions are observed in the FKS1 structures, suggesting active FKS1–membrane interactions. Echinocandin-resistant mutations are clustered at a region near TM5–6 and TM8 of FKS1. The structure of FKS1(S643P) reveals altered lipid arrangements in this region, suggesting a drug-resistant mechanism of the mutant enzyme. The structures, the catalytic mechanism and the molecular insights into drug-resistant mutations of FKS1 revealed in this study advance the mechanistic understanding of fungal β-1,3-glucan biosynthesis and establish a foundation for developing new antifungal drugs by targeting FKS. Using cryo-electron microscopy, the molecular architecture and catalytic mechanism of action of the fungal β-1,3-glucan synthase FKS1 are determined. Tags:chaiChangdongCryoelectron microscopyFungiglycobiologyHuHuanhuanhumanities and social sciencesJiaLiumultidisciplinaryNaturenature.compingscienceSunXinlinYang
Wandering with intent at Willunga,Willunga has a broadening village appeal with a recognisable wine style being produced from its foothills environment. Tags:The New Dailythenewdaily.com.au
Teenage environmental activist squares off with famous misogynist,Greta Thunberg has found herself the target of a Twitter attack by an older man, and the back-and-forth has taken social media by storm Tags:The New Dailythenewdaily.com.au
Ed Sheeran wows kids' hospital with impromptu concert,Pop megastar Ed Sheeran has surprised children and staff at a major Melbourne hospital with an impromptu performance. Tags:The New Dailythenewdaily.com.au
Musk reinstates Trump's Twitter account,Musk reinstates Trump's Twitter account,Former US president Donald Trump says he's unlikely to return to Twitter after it's new owner Elon Musk announced his account would be reinstated. Tags:The New Dailythenewdaily.com.au
Politics of broken promises must be played carefully,The worst thing a government can do, according to opposition politicians and some of the commentariat, is to break election promises. Tags:The New Dailythenewdaily.com.au
Three measles cases detected in Victoria,Three measles cases detected in Victoria,Victoria's deputy chief health officer is putting returned travellers on high alert after three new measles cases were detected in the state. Tags:The New Dailythenewdaily.com.au
Peter Bol to race for 800m gold at Paris Olympics,Peter Bol says he has suffered permanent damage to his reputation, but has vowed to push on and chase 800m gold at the Paris Olympics Tags:The New Dailythenewdaily.com.au
Australia joins global no-plastic pledge,Australia joins global no-plastic pledge,Environment Minister Tanya Plibersek says she wants to see a plastic-free Pacific as Australia joins a global push to end plastic pollution worldwide. Tags:The New Dailythenewdaily.com.au
These four graphs reveal how Australia's TV habits are changing,Australian attitudes towards TV viewing are changing rapidly as corporations vie for our attention on new platforms, new data shows. Tags:The New Dailythenewdaily.com.au
Star imports deliver for Sydney FC in A-League Men | The New Daily,Sydney's old guard delivered for Steve Corica as the Sky Blues finally kept an A-League Men's clean sheet in a 2-0 away win over Newcastle. Tags:The New Dailythenewdaily.com.au
Aussie cricketers rally around Cummins after family heartbreak,Australia will wear black arm bands on the second day of the fourth Test against India after the death of captain Pat Cummins' mother Maria. Tags:The New Dailythenewdaily.com.au
Australia still flunks on climate: report,Australia got the worst possible rating of "very low" for everything but climate policy, which was ranked as "low". Tags:The New Dailythenewdaily.com.au
Swimmers hope to smash world record for largest ever skinny dip,Stripped-off swimmers will take to the water off Sydney hoping to smash the world record for the largest ever skinny dip. Tags:The New Dailythenewdaily.com.au
Josh Giddey stars in OKC's NBA win,Australia's Josh Giddey has fallen just shy of a double-double in OKC's victory over Toronto, while there were also NBA wins for the Magic, Celtics and Knicks. Tags:The New Dailythenewdaily.com.au
Indian Wells: : Aussie Jordan Thompson takes down #2 Tsitsipas,Aussie Jordan Thompson has dashed Stefanos Tsitsipas ambition to be No.1 with an exhilarating three-set Indian Wells victory. Tags:The New Dailythenewdaily.com.au
Flood-impacted NSW brace for another soaking,Flood-impacted towns across NSW are on high alert as forecast downpours over the weekend are expected to wreak further damage. Tags:The New Dailythenewdaily.com.au
Australian actress Emily Browning talks about new comedy series,Melbourne-born actress Emily Browning joins forces with a bunch of Aussue actresses and comedians for post-apocalyptic comedy Class of '07. Tags:The New Dailythenewdaily.com.au
Double blow for heavyweight boxer,Health concerns and injuries could seriously delay Australian heavyweight Justis Huni's charge to a world title shot. Tags:The New Dailythenewdaily.com.au
NASA unveils new spacesuit tailored for moon return,NASA has unveiled the first prototype for a newly designed next-generation spacesuit for the first astronauts expected to venture back to the moon. Tags:The New Dailythenewdaily.com.au
Australia's super-rich exposed among world's worst climate emitters,Australian billionaires are among a list of the world's richest people with the worst carbon emissions as the COP27 summit gets underway. Tags:The New Dailythenewdaily.com.au
Dutton's absence from NSW election 'remarkable': PM,The prime minister has joined the NSW election campaign to lob bombs at the government, days out from the state election. Tags:The New Dailythenewdaily.com.au
Hard questions after Australia's T20 exit,Australia's inability to put the foot to the throat of opponents has meant that years of a planning for a home Twenty20 World Cup has resulted in an early exit. Tags:The New Dailythenewdaily.com.au
Tributes after Australian star drowns at WA beach,Friends in Australia and overseas are paying tribute to actor Peter Hardy, who drowned at a popular beach in Western Australia last week. Tags:The New Dailythenewdaily.com.au
‘This is all a little surreal’: Bono opens book tour in US,U2 frontman Bono has opened his book tour singing, joking and shouting out his life story to thousands of fans at Manhattan's Beacon Theatre. Tags:The New Dailythenewdaily.com.au
Victoria Liberals at odds expelling MP Deeming,Victorian Liberal leader John Pesutto is facing internal resistance over his move to expel MP Moira Deeming for allegedly bringing the party into disrepute. Tags:The New Dailythenewdaily.com.au
Australians ‘very concerned’ about climate change,A majority of Australians are worried about climate change, according to the latest Climate of the Nation report. Tags:The New Dailythenewdaily.com.au
Taylor Swift smashes records with 10th album,Taylor Swift's Midnights broke records the first day it dropped. Now the singer occupies the top 10 spots on the Billboard chart. Tags:The New Dailythenewdaily.com.au
Close-up picture of ant's face spooks the internet,A close-up shot of an ant's face has transfixed the internet, with many saying they will never look at the common insect the same way. Tags:The New Dailythenewdaily.com.au
Households slammed as budget offers little inflation relief,With annual inflation reaching a 32-year high over the September quarter, food staples were hit hard and its going to get worse. Tags:The New Dailythenewdaily.com.au
Ferrari drivers on top in US GP practice,Carlos Sainz and Charles Leclerc were the fastest in practice for the US Grand Prix, while Daniel Ricciardo finished third in a less represented second session. Tags:The New Dailythenewdaily.com.au
'Seriously impacted': Food prices warning as flood devastate farms,Australians are bracing for the biggest cost of living crisis in 30 years to get even worse as widespread flooding. Tags:The New Dailythenewdaily.com.au
Three ways moving on from Aaron Rodgers impacts Packers
Three ways moving on from Aaron Rodgers impacts Packers,Moving on from a franchise quarterback is a challenging situation for any NFL team. Here are three ways the Packers will be impacted if Rodgers has indeed played his last game as a member of the
DOH warns vs eating seafood from oil spill areas
DOH warns vs eating seafood from oil spill areas,The Department of Health warned the public yesterday against eating fish and other seafood from areas affected by the oil spill.
The post DOH warns vs eating seafood from oil spill areas appeared first
Washington turns to Wall Street to help rescue dying bank
Washington turns to Wall Street to help rescue dying bank,In a scene reminiscent of the last financial crisis, the federal government turned to Wall Street this week for help with a blossoming emergency in the banking sector
Robin Hood of the river! How archerfish evolved to shoot insects out of the air,The oldest surviving written account of Robin Hood is preserved at Cambridge University and dates to sometime in the 15th century. The character, and the story surrounding him, has remained one of the most enduring stories in the Western canon, inspiring ongoing adaptations to stage and screen, including the 2010 adaptation starring Russell Crowe. Tags:evolutionFishInterviewsNewsRobin HoodScienceSYFY InsiderSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIRE
Isn’t it ironic that Mercury, the planet closest to the Sun, has ice on its poles?,Mercury has closer encounters with the Sun than any other planet in the solar system. It seems that such a planet would be doomed to turn into another Arrakis, especially after billions of years of being scorched by radiation. Tags:iceInterviewsMercuryNewsScienceSunSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIRE
What’s on SYFY this week? Nic Cage, 'Jeepers Creepers,' 'Die Hard(er)' & a Vin Diesel double feature,While we patiently wait for Resident Alien to return for the back half of its second season this fall, and for the second season of Chucky to arrive (production is underway now!), there’s still plenty of other cool geeky goodies to check out in the meantime on SYFY. Tags:HorrorMoviesNewsNicolas CageSci FiSYFYSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIREtvVin Diesel
The Faroe Islands is some place to die: Daniel Craig's James Bond gets his own gravestone,Daniel Craig’s final James Bond film, No Time to Die, came out last year, and the Faroe Islands — the location for the movie’s memorable villain’s lair — is marking the end of Daniel Craig’s time as Bond with a proper gravestone. Tags:Daniel CraigJames BondMoviesNewsNo Time to DieSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIRE
'Night Sky': J.K. Simmons & Sissy Spacek hide a galactic secret in trailer for new Amazon sci-fi series,If you ever find a portal to another planet in your backyard, be sure to keep it under wraps for as long as possible. You never know what shady elements might be looking to exploit it for their own nefarious ends. It's the very predicament facing the characters of Night Sky — a new Amazon series debuting on Prime Video late next month. Tags:amazon primeJ.K. SimmonsNewsSci FiScience FictionSissy SpacekSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIRETrailerstv
