Dungannon Swifts' potential of Cup upset surfaced for Dean Shiels as soon as draw was made,Dean Shiels revealed he sensed an upset from the moment his Dungannon Swifts side were handed an Irish Cup quarter-final trip to Cliftonville.
Dungannon Swifts' potential of Cup upset surfaced for Dean Shiels as soon as draw was made
Dean Shiels revealed he sensed an upset from the moment his Dungannon Swifts side were handed an Irish Cup quarter-final trip to Cliftonville.
Charred onions with balsamic, walnuts and ricotta,Brush sweet onions in a balsamic honey glaze, bake until tender and serve with dollops of creamy ricotta for an easy veggie side for 4-6 people Tags:entertainolivemagazine.comrecipesVegetarian
How to get the best home equity loan,In order to get the best home equity loan for their needs homeowners should first do these three things. Tags:cbsnews.commoneywatch managing your money
The biggest flaw in Trump’s offensive against his former fixer,In the hopes of discrediting Michael Cohen, Donald Trump is effectively arguing, “Don’t trust the guy who committed crimes for me!” Tags:MSNBCmsnbc.com
Biggest Twist in Bigg Boss 11: Here's How The Elimination Will Happen This Week,Well, let us tell you this year the controversial reality show is giving the audience a chance to save their favourite contestant with LIVE and in-person voting. Tags:bigg boss 11hina khanLuv TyagiMoviesNews18news18.comShilpa ShindeVikas Gupta
Structural and mechanistic insights into fungal 尾-1,3-glucan synthase FKS1,The membrane-integrated synthase FKS is involved in the biosynthesis of β-1,3-glucan, the core component of the fungal cell wall1,2. FKS is the target of widely prescribed antifungal drugs, including echinocandin and ibrexafungerp3,4. Unfortunately, the mechanism of action of FKS remains enigmatic and this has hampered development of more effective medicines targeting the enzyme. Here we present the cryo-electron microscopy structures of Saccharomyces cerevisiae FKS1 and the echinocandin-resistant mutant FKS1(S643P). These structures reveal the active site of the enzyme at the membrane–cytoplasm interface and a glucan translocation path spanning the membrane bilayer. Multiple bound lipids and notable membrane distortions are observed in the FKS1 structures, suggesting active FKS1–membrane interactions. Echinocandin-resistant mutations are clustered at a region near TM5–6 and TM8 of FKS1. The structure of FKS1(S643P) reveals altered lipid arrangements in this region, suggesting a drug-resistant mechanism of the mutant enzyme. The structures, the catalytic mechanism and the molecular insights into drug-resistant mutations of FKS1 revealed in this study advance the mechanistic understanding of fungal β-1,3-glucan biosynthesis and establish a foundation for developing new antifungal drugs by targeting FKS. Using cryo-electron microscopy, the molecular architecture and catalytic mechanism of action of the fungal β-1,3-glucan synthase FKS1 are determined. Tags:chaiChangdongCryoelectron microscopyFungiglycobiologyHuHuanhuanhumanities and social sciencesJiaLiumultidisciplinaryNaturenature.compingscienceSunXinlinYang
EU Parliament bids to lift immunity for two MEPs in corruption probe,The president of the European Parliament has launched an urgent procedure to waive the immunity of two MEPs following a request from Belgian judicial authorities investigating a major corruption scandal rocking EU politics. Tags:articlebelfasttelegraphbelfasttelegraph.co.ukNewsWORLD
Double rapist Isla Bryson enrolled at college while facing charges,A transgender woman convicted of raping two women while she was a man was enrolled on a college beauty course involving spray tan sessions while facing charges, it has emerged. Tags:belfasttelegraph.co.uk
The Crown star Emma Corrin hopes Oscars will introduce gender neutral categories,The Crown star Emma Corrin hopes Oscars will introduce gender neutral categories,The Crown star Emma Corrin says they hope that the Oscars will opt for gender neutral categories at future ceremonies. Tags:articlebelfasttelegraphbelfasttelegraph.co.ukcultureEntertainmentFilm and TV
Ulster Bank confirms NI job losses as branch closures continue in Republic,Ulster Bank has said 20 workers based in Northern Ireland will be made redundant as a result of its exit from the Republic of Ireland market this year. Tags:belfasttelegraph.co.uk
Norman McBurney: Retiring at 79, logistics company boss who’s sold his business for £138m,Norman McBurney: Retiring at 79, logistics company boss who’s sold his business for £138m,The £138m cash sale of one of Northern Ireland’s biggest logistics firms was prompted by the retirement of its owner whose daughter now becomes managing director. Tags:articlebelfasttelegraphbelfasttelegraph.co.ukBUSINESSFeaturedNewsNorthern Ireland
Alan Cumming returns OBE over concerns of link to ‘toxicity’ of British Empire,Scottish actor Alan Cumming has handed back his OBE due to his “misgivings” with being associated with the “toxicity” of the British Empire. Tags:belfasttelegraph.co.uk
Hospitality firms ‘hugely concerned’ for New Year’s trade after disruption,Hospitality firms ‘hugely concerned’ for New Year’s trade after disruption,Hospitality leaders say venues could see weaker trade over the key New Year period after sales were knocked by strike action. Tags:articlebelfasttelegraphbelfasttelegraph.co.ukNewsTrendingUK
There’s no light at the end of long Covid tunnel for thousands, so what’s being done?,It’s the ticking timebomb that rarely makes front-page news, especially with the pandemic fading from memory. Tags:belfasttelegraph.co.uk
Crowds left waiting at major train stations despite end of RMT rail strike,Crowds left waiting at major train stations despite end of RMT rail strike,Crowds of people were left waiting at major train stations across London and beyond amid ongoing disruption despite the end of a rail strike on Tuesday. Tags:articlebelfasttelegraphbelfasttelegraph.co.ukEditor's PicksNewsUK
Jonathan Rea must contend with a host of skilled World Superbike rookies in new Championship,Jonathan Rea could have some new rivals snapping at his heels in this year’s World Superbike Championship but the Northern Ireland rider has more important matters on his mind. Tags:belfasttelegraph.co.uk
How to toast the festive season every day in December… 10 of the best liquid advent calendars,How to toast the festive season every day in December… 10 of the best liquid advent calendars,Advent calendars have come on a bit. Well more than a bit, actually. At one time they were little more than two pieces of cardboard sandwiched together, with little doors cut into the top layer which opened to reveal not much more than a number and a pretty picture on each day of December leading up to Christmas. Tags:articlebelfasttelegraphbelfasttelegraph.co.ukFood and Drinklifelifestyle
Latest Love Island bombshell aims to bring ‘honesty’ to the villa,Love Island’s latest bombshell, Samie Elishi, says she has “no filter” and is set to bring “honesty” to the villa. Tags:belfasttelegraph.co.uk
Peter Bills: Is that performance against Australia as good as it gets for Ireland without Johnny Sexton?,Peter Bills: Is that performance against Australia as good as it gets for Ireland without Johnny Sexton?,Another Irish win, an unbeaten autumn programme and Ireland remain top of the world rankings. Tags:articlebelfasttelegraphbelfasttelegraph.co.ukSportSportsSunday Life
‘When God is given control over your life, He will open doors of opportunity you may have dreamed about but could never achieve’,Tell me about your early background Tags:belfasttelegraph.co.uk
Arlene Philips among stars celebrating 25th year of The Snowman stage show,Arlene Philips among stars celebrating 25th year of The Snowman stage show,Dame Arlene Philips, Gemma Collins and Gok Wan were among the famous faces who have celebrated the 25th anniversary of the stage adaptation of The Snowman. Tags:articlebelfasttelegraphbelfasttelegraph.co.ukEditor's PicksEntertainmentNews
Methody forced to fight all the way while Campbell leave it late in Danske Bank Schools’ Cup last-16 ties,Matthew Rae was a contender for the coolest man in Northern Ireland on Saturday as he kicked Campbell College into the Quarter-Finals of the Danske Bank Schools’ Cup with a dramatic late penalty that secured a 13-10 win over Ballymena Academy. Tags:articlebelfasttelegraphbelfasttelegraph.co.ukrugbySchools CupSport
Olly Murs reads emotional passage Caroline Flack wrote about him before death,Olly Murs reads emotional passage Caroline Flack wrote about him before death,Olly Murs became emotional as he read a passage Caroline Flack wrote about him before her death. Tags:articlebelfasttelegraphbelfasttelegraph.co.ukEntertainmentFilm and TV
The Big Interview: EV infrastructure company co-founder on helping drive electric revolution in NI,The UK Government target of ending sales of new petrol and diesel cars by 2030 to promote electric vehicles (EVs) is an ambitious one. Tags:belfasttelegraph.co.uk
Nicki Minaj, Maluma and Myriam Fares release World Cup anthem,Nicki Minaj, Maluma and Myriam Fares release World Cup anthem,Hip hop star Nicki Minaj has teamed up with Colombian singer-songwriter Maluma and Lebanese singer Myriam Fares for the latest addition to the official soundtrack of the World Cup in Qatar. Tags:articlebelfasttelegraphbelfasttelegraph.co.ukNewsreviewsWORLD
Selling Holywood: NI has its own estate agents for millionaires,Hit reality programmes like Netflix’s Selling Sunset have us glued to our screens, with viewers given access to megabucks properties in places like Los Angeles. Tags:belfasttelegraph.co.uk
Frank Mitchell: Many of the local comics are funnier than established names across the water – but super stardom might elude them forever,Frank Mitchell: Many of the local comics are funnier than established names across the water - but super stardom might elude them forever,It must be amazing to have the ability to practically print money simply because of the thoughts swirling around in your head. I’m thinking about the premier league comedians. People like the returning Peter Kay as well as the likes of Michael McIntyre and Kevin Bridges. For them it’s a case of hire the venue, grab the mic and talk. It’s the talking bit which separates the big money makers from those just getting enough to make it worthwhile. Tags:articlebelfasttelegraphbelfasttelegraph.co.ukCommentFrank MitchellNewsopinion
Belfast City Airport turns 40: A look behind the scenes in getting planes on the go,For many, air travel is something about which to look forward to; for others, it’s a means to an end, a convenient chance to do business in person within a matter of hours. Whether it’s business or pleasure, or a mixture of both, navigating an airport is something that so many of us are familiar. Tags:belfasttelegraph.co.uk
Today at the World Cup: England start training while Wales feel the heat,Today at the World Cup: England start training while Wales feel the heat,England and Wales began their preparations in earnest on Wednesday, while organisers were forced to deny hiring ‘fake fans’ and apologise to a broadcaster. Tags:articlebelfasttelegraphbelfasttelegraph.co.ukFootballreviewsSportSports
Glen’s frustration at All-Ireland error will last… I should know after my own big final controversy,Gary Lineker finds it hard to look back on the day the ball was punched past Peter Shilton into the England net. It was a cheating Diego Maradona who gave Argentina the upper hand and then went on to claim it was the “hand of God”. Tags:belfasttelegraph.co.uk
UK inflation jumps to 41-year high of 11.1% due to surging energy bills,UK inflation jumps to 41-year high of 11.1% due to surging energy bills,Soaring energy bills sent UK inflation to its highest level for 41 years in October as households felt the brunt of the cost of living crisis, according to official figures. Tags:articlebelfasttelegraphbelfasttelegraph.co.ukNewsUK
Beyonce and Adele to battle it out for top prizes at the Grammys,Beyonce and Adele are preparing to face off at the Grammys in a repeat of their 2017 battle. Tags:belfasttelegraph.co.uk
Covid-hit chef serves up a tasty thank-you for medical staff who helped save his life,A chef who spent more than a month in hospital after contracting Covid last year has held a special dinner for the health workers who saved his life. Tags:articlebelfasttelegraphbelfasttelegraph.co.ukNewsNorthern Irelandreviews
Why we may need a St Andrews Mark II to help restore stability at Stormont,You would need to be the ultimate optimist to think we’re close to having Stormont restored. Tags:belfasttelegraph.co.uk
Three ways moving on from Aaron Rodgers impacts Packers
Three ways moving on from Aaron Rodgers impacts Packers,Moving on from a franchise quarterback is a challenging situation for any NFL team. Here are three ways the Packers will be impacted if Rodgers has indeed played his last game as a member of the
DOH warns vs eating seafood from oil spill areas
DOH warns vs eating seafood from oil spill areas,The Department of Health warned the public yesterday against eating fish and other seafood from areas affected by the oil spill.
The post DOH warns vs eating seafood from oil spill areas appeared first
Washington turns to Wall Street to help rescue dying bank
Washington turns to Wall Street to help rescue dying bank,In a scene reminiscent of the last financial crisis, the federal government turned to Wall Street this week for help with a blossoming emergency in the banking sector
Robin Hood of the river! How archerfish evolved to shoot insects out of the air,The oldest surviving written account of Robin Hood is preserved at Cambridge University and dates to sometime in the 15th century. The character, and the story surrounding him, has remained one of the most enduring stories in the Western canon, inspiring ongoing adaptations to stage and screen, including the 2010 adaptation starring Russell Crowe. Tags:evolutionFishInterviewsNewsRobin HoodScienceSYFY InsiderSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIRE
Isn’t it ironic that Mercury, the planet closest to the Sun, has ice on its poles?,Mercury has closer encounters with the Sun than any other planet in the solar system. It seems that such a planet would be doomed to turn into another Arrakis, especially after billions of years of being scorched by radiation. Tags:iceInterviewsMercuryNewsScienceSunSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIRE
What’s on SYFY this week? Nic Cage, 'Jeepers Creepers,' 'Die Hard(er)' & a Vin Diesel double feature,While we patiently wait for Resident Alien to return for the back half of its second season this fall, and for the second season of Chucky to arrive (production is underway now!), there’s still plenty of other cool geeky goodies to check out in the meantime on SYFY. Tags:HorrorMoviesNewsNicolas CageSci FiSYFYSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIREtvVin Diesel
The Faroe Islands is some place to die: Daniel Craig's James Bond gets his own gravestone,Daniel Craig’s final James Bond film, No Time to Die, came out last year, and the Faroe Islands — the location for the movie’s memorable villain’s lair — is marking the end of Daniel Craig’s time as Bond with a proper gravestone. Tags:Daniel CraigJames BondMoviesNewsNo Time to DieSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIRE
'Night Sky': J.K. Simmons & Sissy Spacek hide a galactic secret in trailer for new Amazon sci-fi series,If you ever find a portal to another planet in your backyard, be sure to keep it under wraps for as long as possible. You never know what shady elements might be looking to exploit it for their own nefarious ends. It's the very predicament facing the characters of Night Sky — a new Amazon series debuting on Prime Video late next month. Tags:amazon primeJ.K. SimmonsNewsSci FiScience FictionSissy SpacekSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIRETrailerstv
