Starmer's appointment of Gray as Chief of Staff a "mistake" - Berry | Conservative Home,"The appointment is just another brick in the wall for viewers to say you don't work for us you work for yourself," warns the former Conservative Party Chairman.
Starmer's appointment of Gray as Chief of Staff a "mistake" – Berry | Conservative Home
"The appointment is just another brick in the wall for viewers to say you don't work for us you work for yourself," warns the former Conservative Party Chairman.
Neckties, long shunned in Iran as a "sign of Westernization," are making a timid comeback,While wearing one will still "definitely turn a few heads," Iranians say ties are becoming more common after decades as a taboo accessory. Tags:cbsnews.comFashionIranIslamWORLD
RHOJ controls EMT-associated resistance to chemotherapy,The resistance of cancer cells to therapy is responsible for the death of most patients with cancer1. Epithelial-to-mesenchymal transition (EMT) has been associated with resistance to therapy in different cancer cells2,3. However, the mechanisms by which EMT mediates resistance to therapy remain poorly understood. Here, using a mouse model of skin squamous cell carcinoma undergoing spontaneous EMT during tumorigenesis, we found that EMT tumour cells are highly resistant to a wide range of anti-cancer therapies both in vivo and in vitro. Using gain and loss of function studies in vitro and in vivo, we found that RHOJ—a small GTPase that is preferentially expressed in EMT cancer cells—controls resistance to therapy. Using genome-wide transcriptomic and proteomic profiling, we found that RHOJ regulates EMT-associated resistance to chemotherapy by enhancing the response to replicative stress and activating the DNA-damage response, enabling tumour cells to rapidly repair DNA lesions induced by chemotherapy. RHOJ interacts with proteins that regulate nuclear actin, and inhibition of actin polymerization sensitizes EMT tumour cells to chemotherapy-induced cell death in a RHOJ-dependent manner. Together, our study uncovers the role and the mechanisms through which RHOJ acts as a key regulator of EMT-associated resistance to chemotherapy. RHOJ regulates epithelial-to-mesenchymal-transition-associated resistance to chemotherapy by enhancing the response to replicative stress and activating the DNA damage response, enabling tumour cells to rapidly repair DNA lesions induced by chemotherapy. Tags:BlondeauCancer therapeutic resistanceDebaugnieshumanities and social sciencesjeremyManuelMarie AstridMaudmultidisciplinaryNaturenature.comparentRodr&237;guez AcebessarascienceTumour heterogeneityZocco
In hush money scandal, Republicans need to start pacing themselves,Jim Jordan's hysterical intervention in Donald Trump's hush money scandal is a timely reminder: The GOP really needs to start pacing itself. Tags:MSNBCmsnbc.com
Mario Day 2023: Switch game deals, console bundle, collectibles, LEGO, and more,Mario Day 2023, or MAR10, has officially arrived with deals on Switch games, a new console bundle, collectibles, LEGO, and more! Tags:9to5Toys9to5toys.comApps GamesNewsNintendo
ConHome Defence & Security Conference sketch: Wallace the wine waiter says the Army's kit is "desperately in need of replacement" | Conservative Home,The Defence Secretary said "the real battle for defence" will come in the Comprehensive Spending Review in 2024-25, and "I'm not sure I'll be here in two years". Tags:Alex Chalk MPBen Wallace MPConservative HomeConservativeHomeconservativehome.comFeaturedToryDiary
"If it was going to affect Northern Ireland in a significant way the UK would use the veto" - Heaton-Harris | Conservative Home,The Northern Ireland Secretary says the change to applying EU law is not just a delaying mechanism. But adds that he expects Assembly members "would not use the power trivially." Tags:brexitChris Heaton Harris MPConservative Homeconservativehome.comEuropean Unionvideo
Starmer's appointment of Gray as Chief of Staff a "mistake" - Berry | Conservative Home,"The appointment is just another brick in the wall for viewers to say you don't work for us you work for yourself," warns the former Conservative Party Chairman. Tags:Conservative Homeconservativehome.comJake Berry MPSir Keir Starmer MPSue Grayvideo
Newslinks for Sunday 5th March 2023 | Conservative Home,New law to prevent those arriving in the UK illegally being able to stay | Hancock's plan to ‘frighten the pants off everyone’ about Covid | Gray "may have broken impartiality rules" | Health checks to curb sick leave Tags:Conservative Homeconservativehome.comNewslinksNewslinks March 2023
SNP leadership contender wants independence negotiations to start before a referendum | Conservative Home,Regan argues that if her party won more than 50 per cent of the vote in an election that would be a mandate, as "Westminster isn't going to agree a referendum any time soon." Tags:Conservative Homeconservativehome.comscotlandScottish IndependenceSNPvideo
Adam Wildsmith: Only bold policies on housing and childcare can make reality of Sunak's pro-family rhetoric | Conservative Home,Ease ratios for childminders, stop making small-time carers leap through educational hoops - and face up to the fact we need to build on greenfield sites. Tags:childcareChildrenCommentConservative Homeconservativehome.comDeregulationFeatured
Newslinks for Monday 6th March 2023 | Conservative Home,Sunak is ‘to introduce' new laws to stem cross-Channel migration | He is ‘set to unveil’ multi-billion-pound defence spending boost | Hunt ‘has extra £30 billion’ to ease cost of living crisis | Johnson’s ‘chicken run’ to safer constituency ‘could be blocked’ Tags:Conservative Homeconservativehome.comNewslinksNewslinks March 2023
Ben Ramanauskas: Only blaming Brexit for supermarket shortages is lazy, simplistic, and wrong | Conservative Home,The Government should work to diversify supply chains to increase resilience by making it easier and less expensive for UK supermarkets to import produce from all over the world. Tags:Adam SmithbrexitCommentConservative Homeconservativehome.comFeaturedfree market
Andy Street: The Midlands Rail Hub would deliver a transformational boost to levelling up well beyond our region | Conservative Home,It represents just a tenth of that price tag of Crossrail, yet will improve the economic prospects of huge swathes of the UK. Tags:Andy StreetBirminghamColumnistsConservative Homeconservativehome.comCrossrailFeatured
Chris Heaton-Harris: I'm a former ERG Chairman - and here's why I back this Agreement | Conservative Home,I am sure that once my fellow Eurosceptics have assessed it, they will see that this deal will allow Northern Ireland to prosper while strengthening the bonds that tie our Union together. Tags:CommentConservative Homeconservativehome.comFeatured
"It permanently removes any sense of a border in the Irish Sea." Sunak's Commons statement. Full text. | Conservative Home,Let us seize the opportunity of this moment…The certainty of an agreement that fixes the problems we face…Commands broad support and consensus…And offers us, at last, the freedom to move forward, together. Tags:Conservative Homeconservativehome.comFeaturedNorthern Irelandnorthern ireland protocolParliamentRishi Sunak MP
Sunak's Protocol Deal - and a question for Conservative MPs. Should the perfect be the enemy of the better? | Conservative Home,It's possible that he has pulled off a political coup, begun radically to re-set the UK's relationship with the EU - and created the circumstances in which voters may give him a second look. Tags:Boris Johnson MPConservative Homeconservativehome.comDavid GoodhartDUPFeaturedToryDiary
"In the past, it has been the Conservative tradition that has enabled us to master turbulence and change." Gove's speech on the future of Conservatism. | Conservative Home,The Levelling-Up Secretary was speaking at the launch of Onward's new project designed to kickstart Conservative thinking ahead of the next election. Tags:conservatismConservative Homeconservativehome.comFeaturedMichael Gove MPonwardvideo
Newslinks for Tuesday 28th February 2023 | Conservative Home,We’ve taken back control, says Sunak as he hails breakthrough | Prime Minister heads to Belfast to sell Northern Ireland trade deal | Barclay, Davis, and Raab: It's a complete and utter game changer | Cities set to host fintech hubs to help drive innovation Tags:Conservative Homeconservativehome.comNewslinksNewslinks February 2023
Liam Downer-Sanderson: The Government must stand up for our children, and prioritise families | Conservative Home,Creating and conserving anything worthwhile takes work. Tories know that this applies to Britain’s traditions and liberties. But it also applies to families: families require effort, but those who take up the challenge reap limitless rewards. Tags:ChildrenCommentConservative Homeconservativehome.comEducationfamily policyHighlights
Three ways moving on from Aaron Rodgers impacts Packers
Three ways moving on from Aaron Rodgers impacts Packers,Moving on from a franchise quarterback is a challenging situation for any NFL team. Here are three ways the Packers will be impacted if Rodgers has indeed played his last game as a member of the
DOH warns vs eating seafood from oil spill areas
DOH warns vs eating seafood from oil spill areas,The Department of Health warned the public yesterday against eating fish and other seafood from areas affected by the oil spill.
The post DOH warns vs eating seafood from oil spill areas appeared first
Washington turns to Wall Street to help rescue dying bank
Washington turns to Wall Street to help rescue dying bank,In a scene reminiscent of the last financial crisis, the federal government turned to Wall Street this week for help with a blossoming emergency in the banking sector
Isn’t it ironic that Mercury, the planet closest to the Sun, has ice on its poles?,Mercury has closer encounters with the Sun than any other planet in the solar system. It seems that such a planet would be doomed to turn into another Arrakis, especially after billions of years of being scorched by radiation. Tags:iceInterviewsMercuryNewsScienceSunSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIRE
Full trailer for 'Strange New Worlds' feels like old school 'Star Trek' adventure fans know and love,It's been almost three years since we've seen Anson Mount play Captain Christopher Pike in a Star Trek series. Mount's version of the character — a figure dating back to Star Trek's original unaired pilot episode nearly 60 years ago — was a major player in the second season of Discovery, and popped up again in the Short Treks anthology series. Both those appearances came to a halt in 2019. Tags:Anson MountNewsParamountStar TrekStar Trek Strange New WorldsSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIRETrailerstv
