In hush money scandal, Republicans need to start pacing themselves,Jim Jordan's hysterical intervention in Donald Trump's hush money scandal is a timely reminder: The GOP really needs to start pacing itself. Tags:MSNBCmsnbc.com
Mario Day 2023: Switch game deals, console bundle, collectibles, LEGO, and more,Mario Day 2023, or MAR10, has officially arrived with deals on Switch games, a new console bundle, collectibles, LEGO, and more! Tags:9to5Toys9to5toys.comApps GamesNewsNintendo
Trump clown show: See key witness scorch Trump ally’s testimony,Moments after a Trump ally Bob Costello testified to a New York grand jury, Michael Cohen joins “The Beat” for instant reaction. Cohen’s appearance comes as Trump braces for possible indictment. Cohen tells MSNBC Chief Legal Correspondent Ari Melber Costello is “a clown” -- adding most of what he claimed about Cohen “will be proven to be inaccurate.” On the hush money payment, Cohen says “I didn't sleep with Stormy Daniels… Donald did.” (This is an excerpt of the full discussion that aired on MSNBC). Check out the video playlist for "The Beat with Ari Melber": www.msnbc.com/ari Tags:MSNBCmsnbc.com
Berlin holds funeral for human bone fragments held by the Nazis "to grant peace to all the victims",The site where the bones were found was once home to a hub for Nazi scientists during World War II, including Josef Mengele, notorious for his experiments on prisoners in the Auschwitz concentration camp. Tags:cbsnews.comGermanyNaziWORLD
Structural and mechanistic insights into fungal 尾-1,3-glucan synthase FKS1,The membrane-integrated synthase FKS is involved in the biosynthesis of β-1,3-glucan, the core component of the fungal cell wall1,2. FKS is the target of widely prescribed antifungal drugs, including echinocandin and ibrexafungerp3,4. Unfortunately, the mechanism of action of FKS remains enigmatic and this has hampered development of more effective medicines targeting the enzyme. Here we present the cryo-electron microscopy structures of Saccharomyces cerevisiae FKS1 and the echinocandin-resistant mutant FKS1(S643P). These structures reveal the active site of the enzyme at the membrane–cytoplasm interface and a glucan translocation path spanning the membrane bilayer. Multiple bound lipids and notable membrane distortions are observed in the FKS1 structures, suggesting active FKS1–membrane interactions. Echinocandin-resistant mutations are clustered at a region near TM5–6 and TM8 of FKS1. The structure of FKS1(S643P) reveals altered lipid arrangements in this region, suggesting a drug-resistant mechanism of the mutant enzyme. The structures, the catalytic mechanism and the molecular insights into drug-resistant mutations of FKS1 revealed in this study advance the mechanistic understanding of fungal β-1,3-glucan biosynthesis and establish a foundation for developing new antifungal drugs by targeting FKS. Using cryo-electron microscopy, the molecular architecture and catalytic mechanism of action of the fungal β-1,3-glucan synthase FKS1 are determined. Tags:chaiChangdongCryoelectron microscopyFungiglycobiologyHuHuanhuanhumanities and social sciencesJiaLiumultidisciplinaryNaturenature.compingscienceSunXinlinYang
I used OpenAI’s new tech to transcribe audio right on my laptop,OpenAI has released an open-source transcription program called Whisper. While it’s mainly aimed at researchers and developers, it turns out to be really useful for journalists, too. Tags:front pageThe Vergetheverge.com
The best deals on MacBooks right now,Apple’s macOS-powered laptops come in a few different models. If you are in the market for a new Apple computer but don’t want to spend a ton of money, here are the best deals available on the M1 and M2 MacBook Air and MacBook Pro, as well as the M2 Mac Mini. Tags:front pageThe Vergetheverge.com
Now’s the time to buy last year’s iPad,This year’s latest iPads don’t bring a lot to the table, which means you can save a ton of money on last year’s models and not give up much. Here are recommendations for which iPads to buy instead of the latest and greatest. Tags:front pageThe Vergetheverge.com
The next Sims will have both solo play and multiplayer,During a Sims livestream, EA announced that Project Rene, the next-generation Sims game, will have both single-player and multiplayer components when it launches on PC and mobile. Tags:front pageThe Vergetheverge.com
Any video conferencing app can use the iPad Pro’s fancy zoom and pan camera,Apple confirms that its Center Stage digital pan and zoom tech can be used by any videoconferencing app, not just FaceTime, opening the door for improved Zoom meetings and Microsoft Teams e-learning. Tags:front pageThe Vergetheverge.com
Google cuts 12,000 jobs in latest round of big tech layoffs,Google is the latest big tech firm to announce layoffs, with CEO Sundar Pichai telling staff on Friday that the company will be cutting around 12,000 jobs. Pichai says Google needs to focus on a few key areas, including AI. Tags:front pageThe Vergetheverge.com
Just 10 percent of the new Postal Service fleet will be electric,The new fleet of USPS mail trucks, revealed this week, will be mostly gas-powered according to chief Louis DeJoy. President Biden wants to convert the entire government fleet to electric vehicles, but that will be difficult without the USPS hopping on board. Tags:front pageThe Vergetheverge.com
Elon Musk says Tesla made ‘significant mistakes’ with solar roof project,Tesla CEO Elon Musk made a rare admission during a call with investors, saying that his company was way off in estimating the difficulty of its solar roof project. There are all kinds of issues with existing roofs that could make the price of a solar roof installation skyrocket, he said. Tags:front pageThe Vergetheverge.com
Razer’s Barracuda Pro is its latest do-it-all gaming headset,Razer has announced a slate of new wireless gaming headsets, the $159.99 Barracuda and the $249.99 Barracuda Pro. Each feature dual wireless connectivity, while the Pro feature better audio hardware. Tags:front pageThe Vergetheverge.com
Here are the best iPad deals right now,Hoping for a discount on one of Apple’s premium tablets? Whether you’re looking for the entry-level iPad, the M2 iPad Pro, the 2022 iPad Air, or the iPad Mini, we’re keeping a running list of all the best deals. Tags:front pageThe Vergetheverge.com
Lenovo’s high-end Legion Slim gaming laptops get new AI chips to “optimize cooling”,Lenovo has shown off the eighth generation of its Legion Slim gaming laptops. The new Slim 7, Slim 7i, Slim 5, and Slim 5i come with an AI chip that will dynamically adjust power and cooling for minimum noise and maximum performance. The models will be available throughout April and May. Tags:front pageThe Vergetheverge.com
The FTC sues TurboTax to stop ‘misleading’ ads for free tax prep software,The Federal Trade Commission says the ads for Intuit’s TurboTax software— some of which consist of the word “free” repeated over and over— are misleading, as many people aren’t eligible for its free products. Tags:front pageThe Vergetheverge.com
Hand Mirror uses Apple’s MacBook notch in a wonderfully clever way,Hand Mirror is a free Mac utility that lets you quickly preview your webcam view. A new in-app purchase lets you click behind the notch on Apple laptops for the useful feature. Tags:front pageThe Vergetheverge.com
Turtle Beach unveils ultra-silent Stealth Pro wireless gaming headset,Turtle Beach has announced the Stealth Pro, its latest flagship wireless gaming headset equipped with “unrivaled active noise cancellation” and a swappable two-battery system. Tags:front pageThe Vergetheverge.com
LG is quitting the smartphone business,LG is exiting the smartphone market, the company confirmed today. The division has lost the company billions over the past five years, as it’s lost increasing amounts of market share to rivals. Tags:front pageThe Vergetheverge.com
Amazon suspends Virginia HQ2 construction in latest cost-cutting move,Amazon is halting construction on its second headquarters in Arlington, Virginia. While the first phase of the project is set to be completed in June, the company’s pausing the second phase located across the street. Tags:front pageThe Vergetheverge.com
Snapchat is releasing its own AI chatbot powered by ChatGPT,The My AI bot uses OpenAI technology and will initially only be available to paying Snapchat Plus subscribers. Snap CEO Evan Spiegel says it’s just the beginning for the company’s generative AI plans. Tags:front pageThe Vergetheverge.com
Paradox reveals Sims competitor Life by You,Paradox Interactive announced Life by You, a new Sims-style life simulation game led by Second Life developer Rod Humble. It’s coming to PC (via Steam and the Epic Games Store) as an early access game in September. Tags:front pageThe Vergetheverge.com
The USPS proposes a new mail delivery fleet that’s 40 percent electric,The postal service has announced that it’s upping the number of electric delivery vehicles it plans on buying from around 20 percent to 40 percent. Tags:front pageThe Vergetheverge.com
Marvel Studios VFX head Victoria Alonso is out,Victoria Alonso, Marvel’s longtime head of post-production, VFX, and animation, is parting ways with the entertainment giant after almost 17 years of producing and cultivating the MCU. Tags:front pageThe Vergetheverge.com
US Postal Service to purchase 66,000 electric delivery vehicles in major shift,The US Postal Service is upgrading its deal to replace its aging fleet with 66,000 EVs. The agency is spending $9.6 billion on a total of 106,000 new vehicles, including $3 billion from the Inflation Reduction Act. Tags:front pageThe Vergetheverge.com
Zack Snyder is making an RPG that’s on a “ridiculous scale”,Zack Snyder is working on an RPG set in the universe of his forthcoming Netflix sci-fi movie Rebel Moon, and he’s teasing that it will be on a “ridiculous scale.” Tags:front pageThe Vergetheverge.com
Aqara unveils affordable new smart security products,A new LED strip, presence detection sensor, video doorbell, and smart lock have been announced at CES by smart home gadget maker Aqara. Tags:front pageThe Vergetheverge.com
Wahoo! Turns out Chris Pratt can do a Mario voice,In a new interview to promote The Super Mario Bros. Movie, Chris Pratt shared a Mario voice that actually sounds almost exactly like the one from the video games. Tags:front pageThe Vergetheverge.com
Meta is laying off 10,000 more employees in a series of cuts,Meta has announced that it’s cutting thousands more jobs. This comes just months after Meta laid off 11,000 workers and comes as part of CEO Mark Zuckerberg’s goal of making this the “year of efficiency.” Tags:front pageThe Vergetheverge.com
USPS will order 9,250 Ford E-Transit EVs and 14,000 EV chargers,The USPS is ordering thousands of electric vehicles from Ford as well as EV charging infrastructure to help with its electrification goals. It plans to put at least some of them in use in the coming years. Tags:front pageThe Vergetheverge.com
Humble Bundle’s latest bundle benefits earthquake relief in Turkey and Syria,Humble Bundle’s Türkiye-Syria earthquake relief bundle goes directly to the nonprofit organizations providing aid to both countries following last month’s devastating earthquake. Tags:front pageThe Vergetheverge.com
These new wireless PS5 headsets from Turtle Beach don’t make much sense,Turtle Beach is rolling out PlayStation versions of its Stealth 700 and 600 Gen 2 Max wireless headsets. Strangely, they don’t feature Xbox support even though the designed for Xbox versions released in early 2022 support PlayStation. Tags:front pageThe Vergetheverge.com
Apple Mac Mini (2023) review: Mac Studio junior,Apple’s new Mac Mini has faster performance, upgraded Wi-Fi, and offers a choice between two processors. The M2 model is perfect for everyday tasks, while the more powerful M2 Pro is the better choice for creative work. Tags:front pageThe Vergetheverge.com
MSCHF’s free dating simulator that can prepare your taxes is no longer on Steam,MSCHF’s new game, Tax Heaven 3000, is a free dating simulator that can prepare your 2022 federal tax return. It’s out on April 4th. Sometime on Wednesday, it was pulled from Steam Tags:front pageThe Vergetheverge.com
How to set up two-factor authentication on your online services,While 2FA doesn’t totally cloak you from potential hackers, it is an important step in preventing your account from being accessed by unauthorized users. Here’s how to enable 2FA on your accounts across the web. Tags:The Vergetheverge.com
Three ways moving on from Aaron Rodgers impacts Packers
Three ways moving on from Aaron Rodgers impacts Packers,Moving on from a franchise quarterback is a challenging situation for any NFL team. Here are three ways the Packers will be impacted if Rodgers has indeed played his last game as a member of the
DOH warns vs eating seafood from oil spill areas
DOH warns vs eating seafood from oil spill areas,The Department of Health warned the public yesterday against eating fish and other seafood from areas affected by the oil spill.
The post DOH warns vs eating seafood from oil spill areas appeared first
Washington turns to Wall Street to help rescue dying bank
Washington turns to Wall Street to help rescue dying bank,In a scene reminiscent of the last financial crisis, the federal government turned to Wall Street this week for help with a blossoming emergency in the banking sector
Isn’t it ironic that Mercury, the planet closest to the Sun, has ice on its poles?,Mercury has closer encounters with the Sun than any other planet in the solar system. It seems that such a planet would be doomed to turn into another Arrakis, especially after billions of years of being scorched by radiation. Tags:iceInterviewsMercuryNewsScienceSunSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIRE
Full trailer for 'Strange New Worlds' feels like old school 'Star Trek' adventure fans know and love,It's been almost three years since we've seen Anson Mount play Captain Christopher Pike in a Star Trek series. Mount's version of the character — a figure dating back to Star Trek's original unaired pilot episode nearly 60 years ago — was a major player in the second season of Discovery, and popped up again in the Short Treks anthology series. Both those appearances came to a halt in 2019. Tags:Anson MountNewsParamountStar TrekStar Trek Strange New WorldsSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIRETrailerstv
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