A major bank failed. Here’s why it’s not 2008 again,The financial institution best known for its relationships with high-flying world technology startups and venture capital, Silicon Valley Bank, experienced one of the oldest problems in banking — a bank run — which led to its failure on Friday
A major bank failed. Here’s why it’s not 2008 again
The financial institution best known for its relationships with high-flying world technology startups and venture capital, Silicon Valley Bank, experienced one of the oldest problems in banking — a bank run — which led to its failure on Friday
RHOJ controls EMT-associated resistance to chemotherapy,The resistance of cancer cells to therapy is responsible for the death of most patients with cancer1. Epithelial-to-mesenchymal transition (EMT) has been associated with resistance to therapy in different cancer cells2,3. However, the mechanisms by which EMT mediates resistance to therapy remain poorly understood. Here, using a mouse model of skin squamous cell carcinoma undergoing spontaneous EMT during tumorigenesis, we found that EMT tumour cells are highly resistant to a wide range of anti-cancer therapies both in vivo and in vitro. Using gain and loss of function studies in vitro and in vivo, we found that RHOJ—a small GTPase that is preferentially expressed in EMT cancer cells—controls resistance to therapy. Using genome-wide transcriptomic and proteomic profiling, we found that RHOJ regulates EMT-associated resistance to chemotherapy by enhancing the response to replicative stress and activating the DNA-damage response, enabling tumour cells to rapidly repair DNA lesions induced by chemotherapy. RHOJ interacts with proteins that regulate nuclear actin, and inhibition of actin polymerization sensitizes EMT tumour cells to chemotherapy-induced cell death in a RHOJ-dependent manner. Together, our study uncovers the role and the mechanisms through which RHOJ acts as a key regulator of EMT-associated resistance to chemotherapy. RHOJ regulates epithelial-to-mesenchymal-transition-associated resistance to chemotherapy by enhancing the response to replicative stress and activating the DNA damage response, enabling tumour cells to rapidly repair DNA lesions induced by chemotherapy. Tags:BlondeauCancer therapeutic resistanceDebaugnieshumanities and social sciencesjeremyManuelMarie AstridMaudmultidisciplinaryNaturenature.comparentRodr&237;guez AcebessarascienceTumour heterogeneityZocco
California deputy killed by driver, suspect dies in shootout,Authorities say a Southern California sheriff’s deputy has been shot and killed by a man with a violent criminal history during a traffic stop Tags:ABC NewsCaliforniaGeneral newsgo.comLaw enforcementLos Angelesus
Suspected Stockton serial killer Wesley Brownlee tied to 4 other slayings, prosecutor says,Prosecutors have charged Wesley Brownlee in a total of seven deaths in Northern California since April 2021. Tags:CaliforniaCBSNewscbsnews.comCrimeShootingsStocktonU.S.
California deputy killed by driver, suspect dies in shootout - WTOP News,A Southern California sheriff’s deputy was shot and killed Thursday by a man with a violent criminal history during a traffic stop and the suspect later died in a shootout on a freeway, authorities said. Tags:Californianational newsriverside county sheriff chad biancotraffic stopWTOP Newswtop.com
Former Santa Monica mayor Rex Minter ID'd as plane crash victim,A passenger who died after a small plane crashed onto the Santa Monica beach has been identified as the city’s former mayor, 95-year-old Rex Minter, officials confirmed. Tags:CaliforniacrashesmayorsNew York PostNewsnypost.complane crashessanta monica
Prosecutor: 4 More Slayings Tied to California Serial Killer,STOCKTON, Calif. (AP) — A man suspected in Northern California serial killings has been charged in four additional slayings this week, bringing the total to seven deaths since April 2021, authorities said. Tags:Associated PressCaliforniaCalifornia NewsCrimeUS News & World Reportusnews.com
Three ways moving on from Aaron Rodgers impacts Packers
Three ways moving on from Aaron Rodgers impacts Packers,Moving on from a franchise quarterback is a challenging situation for any NFL team. Here are three ways the Packers will be impacted if Rodgers has indeed played his last game as a member of the
DOH warns vs eating seafood from oil spill areas
DOH warns vs eating seafood from oil spill areas,The Department of Health warned the public yesterday against eating fish and other seafood from areas affected by the oil spill.
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Washington turns to Wall Street to help rescue dying bank
Washington turns to Wall Street to help rescue dying bank,In a scene reminiscent of the last financial crisis, the federal government turned to Wall Street this week for help with a blossoming emergency in the banking sector
Robin Hood of the river! How archerfish evolved to shoot insects out of the air,The oldest surviving written account of Robin Hood is preserved at Cambridge University and dates to sometime in the 15th century. The character, and the story surrounding him, has remained one of the most enduring stories in the Western canon, inspiring ongoing adaptations to stage and screen, including the 2010 adaptation starring Russell Crowe. Tags:evolutionFishInterviewsNewsRobin HoodScienceSYFY InsiderSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIRE
Isn’t it ironic that Mercury, the planet closest to the Sun, has ice on its poles?,Mercury has closer encounters with the Sun than any other planet in the solar system. It seems that such a planet would be doomed to turn into another Arrakis, especially after billions of years of being scorched by radiation. Tags:iceInterviewsMercuryNewsScienceSunSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIRE
What’s on SYFY this week? Nic Cage, 'Jeepers Creepers,' 'Die Hard(er)' & a Vin Diesel double feature,While we patiently wait for Resident Alien to return for the back half of its second season this fall, and for the second season of Chucky to arrive (production is underway now!), there’s still plenty of other cool geeky goodies to check out in the meantime on SYFY. Tags:HorrorMoviesNewsNicolas CageSci FiSYFYSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIREtvVin Diesel
The Faroe Islands is some place to die: Daniel Craig's James Bond gets his own gravestone,Daniel Craig’s final James Bond film, No Time to Die, came out last year, and the Faroe Islands — the location for the movie’s memorable villain’s lair — is marking the end of Daniel Craig’s time as Bond with a proper gravestone. Tags:Daniel CraigJames BondMoviesNewsNo Time to DieSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIRE
'Night Sky': J.K. Simmons & Sissy Spacek hide a galactic secret in trailer for new Amazon sci-fi series,If you ever find a portal to another planet in your backyard, be sure to keep it under wraps for as long as possible. You never know what shady elements might be looking to exploit it for their own nefarious ends. It's the very predicament facing the characters of Night Sky — a new Amazon series debuting on Prime Video late next month. Tags:amazon primeJ.K. SimmonsNewsSci FiScience FictionSissy SpacekSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIRETrailerstv
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