Huge pop star looks unrecognisable with a shaggy beard – can you guess who?,ZAYN Malik looked completely different as he showed off his new clothing collection. Fans are used to seeing the singer, 29, with a shaved head and short beard. But the former One Direction member …
Huge pop star looks unrecognisable with a shaggy beard – can you guess who?
ZAYN Malik looked completely different as he showed off his new clothing collection. Fans are used to seeing the singer, 29, with a shaved head and short beard. But the former One Direction member …
CAF announces $4 billion water project financing for Latam, Caribbean,"Depending on the country and its needs we are going to see which are the projects that we're going to finance," Asinelli said ahead of the announcement, made on the sidelines of the United Nations Water Conference. He said part of the importance of investment in water and sanitation is it affects policies in other sectors including health and education. Tags:Devdiscoursedevdiscourse.comWASH
Real-time quantum error correction beyond break-even,The ambition of harnessing the quantum for computation is at odds with the fundamental phenomenon of decoherence. The purpose of quantum error correction (QEC) is to counteract the natural tendency of a complex system to decohere. This cooperative process, which requires participation of multiple quantum and classical components, creates a special type of dissipation that removes the entropy caused by the errors faster than the rate at which these errors corrupt the stored quantum information. Previous experimental attempts to engineer such a process1–7 faced the generation of an excessive number of errors that overwhelmed the error-correcting capability of the process itself. Whether it is practically possible to utilize QEC for extending quantum coherence thus remains an open question. Here we answer it by demonstrating a fully stabilized and error-corrected logical qubit whose quantum coherence is substantially longer than that of all the imperfect quantum components involved in the QEC process, beating the best of them with a coherence gain of G = 2.27 ± 0.07. We achieve this performance by combining innovations in several domains including the fabrication of superconducting quantum circuits and model-free reinforcement learning. A study demonstrates the extension of a lifetime of a quantum memory using active quantum error correction and reinforcement learning. Tags:abEickbuschhumanities and social sciencesimultidisciplinaryNaturenature.comquantum informationqubitsRoyersscienceSinghSivakTsioutsiosV. V.
Thalamus drives vocal onsets in the zebra finch courtship song,While motor cortical circuits contain information related to specific movement parameters1, long-range inputs also have a critical role in action execution2,3. Thalamic projections can shape premotor activity2–6 and have been suggested7 to mediate the selection of short, stereotyped actions comprising more complex behaviours8. However, the mechanisms by which thalamus interacts with motor cortical circuits to execute such movement sequences remain unknown. Here we find that thalamic drive engages a specific subpopulation of premotor neurons within the zebra finch song nucleus HVC (proper name) and that these inputs are critical for the progression between vocal motor elements (that is, ‘syllables’). In vivo two-photon imaging of thalamic axons in HVC showed robust song-related activity, and online perturbations of thalamic function caused song to be truncated at syllable boundaries. We used thalamic stimulation to identify a sparse set of thalamically driven neurons within HVC, representing ~15% of the premotor neurons within that network. Unexpectedly, this population of putative thalamorecipient neurons is robustly active immediately preceding syllable onset, leading to the possibility that thalamic input can initiate individual song components through selectively targeting these ‘starter cells’. Our findings highlight the motor thalamus as a director of cortical dynamics in the context of an ethologically relevant behavioural sequence. In songbird, thalamus drives a small population of premotor neurons to initiate transitions between song syllables. Tags:Ackert SmithAriadnabirdsongCorredera AsensioDevorahelmalehFelix W.humanities and social sciencesKranzLyn A.MargotmollmultidisciplinaryNaturenature.comNeural circuitsscience
Hate working weekends? Try a time tracker,The thought of time sheets in academia might fill you with horror, but they could help you to prioritize tasks, says Inger Mewburn. Tags:CareersIngerLab lifeMewburnnature.com
Ultrafast structural changes direct the first molecular events of vision,Vision is initiated by the rhodopsin family of light-sensitive G protein-coupled receptors (GPCRs)1. A photon is absorbed by the 11-cis retinal chromophore of rhodopsin, which isomerizes within 200 femtoseconds to the all-trans conformation2, thereby initiating the cellular signal transduction processes that ultimately lead to vision. However, the intramolecular mechanism by which the photoactivated retinal induces the activation events inside rhodopsin remains experimentally unclear. Here we use ultrafast time-resolved crystallography at room temperature3 to determine how an isomerized twisted all-trans retinal stores the photon energy that is required to initiate the protein conformational changes associated with the formation of the G protein-binding signalling state. The distorted retinal at a 1-ps time delay after photoactivation has pulled away from half of its numerous interactions with its binding pocket, and the excess of the photon energy is released through an anisotropic protein breathing motion in the direction of the extracellular space. Notably, the very early structural motions in the protein side chains of rhodopsin appear in regions that are involved in later stages of the conserved class A GPCR activation mechanism. Our study sheds light on the earliest stages of vision in vertebrates and points to fundamental aspects of the molecular mechanisms of agonist-mediated GPCR activation. One picosecond after photoactivation, isomerized retinal pulls away from half of its numerous interactions with its binding pocket, and the excess of the photon energy is released through an anisotropic protein breathing motion in the direction of the extracellular space. Tags:Christopher J.giorgiaGruhlhumanities and social sciencesMatthew JMilnemultidisciplinaryNaturenature.comOrtolaniPhotobiologyRodriguessciencethomasTobiasvisual systemWeinertX ray crystallography
Immunoglobulin M perception by Fc渭R,Immunoglobulin M (IgM) is the first antibody to emerge during embryonic development and the humoral immune response1. IgM can exist in several distinct forms, including monomeric, membrane-bound IgM within the B cell receptor (BCR) complex, pentameric and hexameric IgM in serum and secretory IgM on the mucosal surface. FcμR, the only IgM-specific receptor in mammals, recognizes different forms of IgM to regulate diverse immune responses2–5. However, the underlying molecular mechanisms remain unknown. Here we delineate the structural basis of the FcμR–IgM interaction by crystallography and cryo-electron microscopy. We show that two FcμR molecules interact with a Fcμ-Cμ4 dimer, suggesting that FcμR can bind to membrane-bound IgM with a 2:1 stoichiometry. Further analyses reveal that FcμR-binding sites are accessible in the context of IgM BCR. By contrast, pentameric IgM can recruit four FcμR molecules to bind on the same side and thereby facilitate the formation of an FcμR oligomer. One of these FcμR molecules occupies the binding site of the secretory component. Nevertheless, four FcμR molecules bind to the other side of secretory component-containing secretory IgM, consistent with the function of FcμR in the retrotransport of secretory IgM. These results reveal intricate mechanisms of IgM perception by FcμR. The structural basis for the molecular mechanism of recognition of different IgM forms by the IgM receptor FcμR is determined using crystallography and cryo-electron microscopy. Tags:antibodiesChenggongCryoelectron microscopyHaohumanities and social sciencesJILimultidisciplinaryNaturenature.comRuixuescienceShenwangX ray crystallographyYaxinYuxinZhang
Acceleration of 1I/鈥極umuamua from radiolytically produced H2 in H2O ice,In 2017, 1I/‘Oumuamua was identified as the first known interstellar object in the Solar System1. Although typical cometary activity tracers were not detected2–6, ‘Oumuamua showed a notable non-gravitational acceleration7. So far, there has been no explanation that can reconcile these constraints8. Owing to energetic considerations, outgassing of hyper-volatile molecules is favoured over heavier volatiles such as H2O and CO2 (ref. 9). However, there are theoretical and/or observational inconsistencies10 with existing models invoking the sublimation of pure H2 (ref. 9), N2 (ref. 11) and CO (ref. 12). Non-outgassing explanations require fine-tuned formation mechanisms and/or unrealistic progenitor production rates7,13–15. Here we report that the acceleration of ‘Oumuamua is due to the release of entrapped molecular hydrogen that formed through energetic processing of an H2O-rich icy body. In this model, ‘Oumuamua began as an icy planetesimal that was irradiated at low temperatures by cosmic rays during its interstellar journey, and experienced warming during its passage through the Solar System. This explanation is supported by a large body of experimental work showing that H2 is efficiently and generically produced from H2O ice processing, and that the entrapped H2 is released over a broad range of temperatures during annealing of the amorphous water matrix16–22. We show that this mechanism can explain many of ‘Oumuamua’s peculiar properties without fine-tuning. This provides further support3 that ‘Oumuamua originated as a planetesimal relic broadly similar to Solar System comets. Acceleration of ‘Oumuamua is due to the release of entrapped molecular hydrogen formed through energetic processing of an H2O-rich icy body, supporting the idea that it originated as a planetesimal relic similar to Solar System comets. Tags:asteroidsBergnercomets and Kuiper beltDarryl Z.humanities and social sciencesinterstellar mediumJennifer B.multidisciplinaryNaturenature.comscienceSeligman
LEGO Has Revealed a Super Mario 64 Question Mark Block, and It’s Awesome,LEGO has lifted the lid on LEGO 71395 Super Mario 64 Question Mark Block, and it's a glorious must-have for all Mario fans. Tags:cultureGamesNewsNintendo DSSuper Mario 64thatbricksite.com
LEGO Has Revealed a Super Mario 64 Question Mark Block, and It’s Awesome,LEGO has lifted the lid on LEGO 71395 Super Mario 64 Question Mark Block, and it's a glorious must-have for all Mario fans. Tags:cultureGamesNewsNintendo DSSuper Mario 64thatbricksite.com
5 Video Game Sequels We’re Tired of Waiting For,MenStuff: 'We take a look at some of the sequels that we hope to see the light of day.' Tags:cultureGamesmenstuff.co.zaOpinion piece
5 Video Game Sequels We’re Tired of Waiting For,MenStuff: 'We take a look at some of the sequels that we hope to see the light of day.' Tags:cultureGamesmenstuff.co.zaOpinion piece
The music influences of the Beatles and friendship with Paul McCartney on Rusty Anderson is still palpable 60 years later and just as Paul reaches his 80th Birthday.,One of the largest concert tours of the summer recently came to Syracuse University to christen the first major live show as the newly named JMA Wireless Dome. WAER’s John Smith caught up with Paul McCartney’s multi-talented lead guitarist, Solo Singer-Songwriter and National Recording Artist Rusty Anderson. It coincides with the... Tags:cultureNewsBreakNYSyracusewww.waer.org
Robin Thicke & Lil Wayne Perform “Tie My Hands” & “Shooter” Live In A L.A. Restaurant, Wayne Reads Lyrics From His Phone [Video],A couple of days ago on June 9th, Robin Thicke and Lil Wayne put on a surprise live performance for everyone... Tags:CAcultureLos AngelesNewsBreakpopularwww.lilwaynehq.com
Audien Explains How Progressive House Never Died,Audien sat down to discuss his Progressive House Never Died tour, his recent releases, and more before his set at EDC Las Vegas. Audien has become an artist beloved by many around the world since he first emerged on the scene. From his releases that have touched the hearts of millions... Tags:cultureedmidentity.comLas VegasNewsBreakNVpopular
Taylor Swift talks ‘All Too Well’ at Tribeca Festival,NEW YORK (AP) — Fans outside New York’s Beacon Theater were cheering for Taylor Swift before she arrived, belting her songs before she stepped onstage. That energy remained throughout her stop at the 21st Tribeca Festival on Saturday, where Swift discussed transitioning into the director’s chair, the nuances of visual storytelling... Tags:cultureNew York CityNewsBreakNYpodcastswww.wdhn.com
Thomas Rhett Knows How to Do Teens’ TikTok Dances a Little Too Well [Watch],If Thomas Rhett is hoping to embarrass his daughters one day, then he is certainly off to a great start. The father of four recently posted a video of himself impersonating teenagers dancing on social media — a major cringe for any pre-teen who wants to maintain their TikTok... Tags:cultureNewsBreakquickcountry.comTheater and Dance
Where to stream The Time Traveler’s Wife TV series online,The Time Traveler’s Wife is certainly a series to check out during Droughtlander. Where are you going to stream the show online?. We’re looking for TV shows and movies to watch during Droughtlander. The Time Traveler’s Wife is one of the most recent shows to check out. It is based on... Tags:claireandjamie.comcultureNewsBreakpodcaststv series
The Snark: Real Housewives, Catfish & Johnny Depp,CHARLOTTE, N.C. – On “The Real Housewives of Beverly Hills,” the ladies take a trip to Mexico. After landing, Garcelle makes a prediction about Dorit. “The One That Got Away... Tags:CharlottecultureEditor's PicksNCNewsBreakwww.wccbcharlotte.com
The Boys season 3 premiere recap: Payback,Season 2 of Amazon Prime’s The Boys ended with Nazi supe Stormfront (Aya Cash) absolutely mutilated by Ryan (Cameron Crovetti), the superpowered biological son of Homelander (Antony Starr). Unfortunately, Ryan’s mother, Becca Butcher (Shantel VanSanten), accidentally gets killed by his superpowered wrath against Stormfront. One should also... Tags:cultureNewsBreakshowsnob.comtv series
Tributes Pour Out For TikTok Star Cooper Noriega After Sudden Death,TikTok star Cooper Noriega died suddenly on Friday (June 10), causing an influx of tributes on social media from some of his closest friends. Among those who paid their respects were Dixie D'Amelio, Jaden Hossler, Sabrina Quesada, Nessa Barrett, Josh Richards and Amelie Zilber. Noriega was found unconscious in... Tags:CAcultureLos AngelesNewsBreakpodcastswww.iheart.com
31 Years Ago: Skid Row Release ‘Slave to the Grind’,Many commercial metal bands that garnered mainstream attention in the ‘80s and ‘90s suddenly became tamer and more calculated. In addition to handlers and label executives who urged groups to tone down their sound to reach the next level of popularity (see Motley Crue, Ratt, Guns N’ Roses and Dokken for... Tags:classicrock1051.comcultureNewsBreakpopularRock music
Amazing Norwegian Phenom Aurora in Boston at End of U.S. Tour,Amazing Norwegian Phenom Aurora in Boston at End of U.S. Tour. Aurora is a Norwegian singer, songwriter, dancer and record producer who has captured the world and blown up in the past year. She has been making music since the age of 6 and has been active since she was 16,... Tags:bostoncultureMAmusicfestnews.comNewsBreak
Game review: Halo Infinite Campaign (Xbox Series X) – FutureFive NZ,It has been exactly 20 years since the first Halo game made the original Xbox console famous in 2001. While the original developer Bungie left the franchise to make Destiny a few years ago, the last few games have now been made by 343 Industries. Tags:cultureEditor's Picksfuturefive.co.nzGamesHalo InfiniteReviewXbox Series X
Halo Infinite – From disaster to triumph, details of its development,Developing a blockbuster-like video game like Halo Infinite is already complex on its own, but when it takes place during a global pandemic, things get even more complicated. Tags:articlecalifornia18.comcultureFeaturedGamesHalo InfinitePCXbox OneXbox Series X
Halo Infinite Campaign Review – Xbox Series X – Pixel Cereal,Pixel Cereal It’s been 6 long years since we had a chance to step into the shoes of Master Chief. When last we saw him, he was being hunted down by Spartan Locke, while trying to track down and convince Cortana to stand down from her decision to use the Guardians as a means of forcibly achieving galactic peace. Tags:cultureFeaturedGamesHalo Infinitepixelcereal.comReviewXbox Series X
Forza Motorsport Developer Update: 'Super Realistic' New Suspension Model,Forza Motorsport creative director Chris Esaki returned to the hot seat on the latest Forza Monthly live stream to discuss more details on the upcoming Forza Motorsport, specifically regarding a new suspension model for the title. Tags:cultureForza MotorsportGamesgtplanet.netNewsPCxboxXbox OneXbox Series X
Druddigon Coming to Pokemon GO During Dragonspiral Descent Event,Druddigon is finally trudging its way into Pokemon GO during the upcoming Dragonspiral Descent event that will feature many Unovan 'mons. Tags:androidcultureFeaturedGamesiPadiPhoneNewsPokemon Gopokemongolive.com
Details emerge on the length and difficulty of Pokémon Legends: Arceus,Shortly after hearing the latest news about Pokémon Legends: Arceus, we have now received more news related to this promising title. This is an interesting round of detail that was offered today. In this case, the information is not officially confirmed and comes from insider Riddler Khu, who has already been sharing supposedly real details. Tags:cultureGamesguide4gamer.comPokémon legends arceuspopularRumorSwitch
Halo Infinite review: Combat finally evolved | Reviews.org,It’s not without its flaws, but none of them hold back Halo Infinite from being a solid return to form for the wayward shooter series. Tags:cultureFeaturedGamesHalo InfinitePCReviewreviews.org
Three ways moving on from Aaron Rodgers impacts Packers
Three ways moving on from Aaron Rodgers impacts Packers,Moving on from a franchise quarterback is a challenging situation for any NFL team. Here are three ways the Packers will be impacted if Rodgers has indeed played his last game as a member of the
DOH warns vs eating seafood from oil spill areas
DOH warns vs eating seafood from oil spill areas,The Department of Health warned the public yesterday against eating fish and other seafood from areas affected by the oil spill.
The post DOH warns vs eating seafood from oil spill areas appeared first
Washington turns to Wall Street to help rescue dying bank
Washington turns to Wall Street to help rescue dying bank,In a scene reminiscent of the last financial crisis, the federal government turned to Wall Street this week for help with a blossoming emergency in the banking sector
Birds sometimes hitch rides on ships—and it's changing the way they migrate,Freighter crews have long told stories of sparrows and nightjars, owls, and herons settling on their boats’ decks. Tags:AnimalsBirdsEnvironmentpopsci.comPopular ScienceWildlife
What we know about hormonal birth control and breast cancer risk,Don't throw out your birth control pills just yet—studies show this risk disappears eventually after stopping hormonal birth control. Tags:CancerdiseasesHealthmedicinepopsci.comPopular ScienceScience
What ancient tsunamis can teach us about future disasters,Gigantic tsunamis have been decimating coastlines since time immemorial. We ignore these prehistoric warnings at our own peril. Tags:Environmentpopsci.comPopular ScienceScienceweather
![Robin Thicke & Lil Wayne Perform “Tie My Hands” & “Shooter” Live In A L.A. Restaurant, Wayne Reads Lyrics From His Phone [Video]](https://img.particlenews.com/img/id/3oreFO_0g7uKPJy00?type=thumbnail_1200x627&limit=20 "Robin Thicke & Lil Wayne Perform “Tie My Hands” & “Shooter” Live In A L.A. Restaurant, Wayne Reads Lyrics From His Phone [Video]")
![Thomas Rhett Knows How to Do Teens’ TikTok Dances a Little Too Well [Watch]](https://img.particlenews.com/img/id/14SQFz_0g7xV0lY00?type=thumbnail_1200x627&limit=20 "Thomas Rhett Knows How to Do Teens’ TikTok Dances a Little Too Well [Watch]")
