BTS’ RM dismisses disbandment rumours: “This is not the end for us”,BTS leader RM has addressed disbandment rumours in a recent post made to fan community platform Weverse. Earlier this week, the K-pop titans announced that they would be “ time to explore some solo projects” during a live broadcast celebrating their ninth anniversary. The boyband are set to embark on an...
BTS’ RM dismisses disbandment rumours: “This is not the end for us”
BTS leader RM has addressed disbandment rumours in a recent post made to fan community platform Weverse. Earlier this week, the K-pop titans announced that they would be “ time to explore some solo projects” during a live broadcast celebrating their ninth anniversary. The boyband are set to embark on an…
In hush money scandal, Republicans need to start pacing themselves,Jim Jordan's hysterical intervention in Donald Trump's hush money scandal is a timely reminder: The GOP really needs to start pacing itself. Tags:MSNBCmsnbc.com
Mario Day 2023: Switch game deals, console bundle, collectibles, LEGO, and more,Mario Day 2023, or MAR10, has officially arrived with deals on Switch games, a new console bundle, collectibles, LEGO, and more! Tags:9to5Toys9to5toys.comApps GamesNewsNintendo
Trump clown show: See key witness scorch Trump ally’s testimony,Moments after a Trump ally Bob Costello testified to a New York grand jury, Michael Cohen joins “The Beat” for instant reaction. Cohen’s appearance comes as Trump braces for possible indictment. Cohen tells MSNBC Chief Legal Correspondent Ari Melber Costello is “a clown” -- adding most of what he claimed about Cohen “will be proven to be inaccurate.” On the hush money payment, Cohen says “I didn't sleep with Stormy Daniels… Donald did.” (This is an excerpt of the full discussion that aired on MSNBC). Check out the video playlist for "The Beat with Ari Melber": www.msnbc.com/ari Tags:MSNBCmsnbc.com
Berlin holds funeral for human bone fragments held by the Nazis "to grant peace to all the victims",The site where the bones were found was once home to a hub for Nazi scientists during World War II, including Josef Mengele, notorious for his experiments on prisoners in the Auschwitz concentration camp. Tags:cbsnews.comGermanyNaziWORLD
Structural and mechanistic insights into fungal 尾-1,3-glucan synthase FKS1,The membrane-integrated synthase FKS is involved in the biosynthesis of β-1,3-glucan, the core component of the fungal cell wall1,2. FKS is the target of widely prescribed antifungal drugs, including echinocandin and ibrexafungerp3,4. Unfortunately, the mechanism of action of FKS remains enigmatic and this has hampered development of more effective medicines targeting the enzyme. Here we present the cryo-electron microscopy structures of Saccharomyces cerevisiae FKS1 and the echinocandin-resistant mutant FKS1(S643P). These structures reveal the active site of the enzyme at the membrane–cytoplasm interface and a glucan translocation path spanning the membrane bilayer. Multiple bound lipids and notable membrane distortions are observed in the FKS1 structures, suggesting active FKS1–membrane interactions. Echinocandin-resistant mutations are clustered at a region near TM5–6 and TM8 of FKS1. The structure of FKS1(S643P) reveals altered lipid arrangements in this region, suggesting a drug-resistant mechanism of the mutant enzyme. The structures, the catalytic mechanism and the molecular insights into drug-resistant mutations of FKS1 revealed in this study advance the mechanistic understanding of fungal β-1,3-glucan biosynthesis and establish a foundation for developing new antifungal drugs by targeting FKS. Using cryo-electron microscopy, the molecular architecture and catalytic mechanism of action of the fungal β-1,3-glucan synthase FKS1 are determined. Tags:chaiChangdongCryoelectron microscopyFungiglycobiologyHuHuanhuanhumanities and social sciencesJiaLiumultidisciplinaryNaturenature.compingscienceSunXinlinYang
Winnie the Pooh: Blood and Honey is just the grim beginning now the classics are coming out of copyright,This perverse slasher flick has been universally panned - but as our favourite characters enter the public domain, we should brace ourselves for more Tags:cultureinews.co.ukuconn edu
Scream VI review: It's time to kill off this anaemic franchise,This latest instalment stabs itself in the foot at the outset by lurching even further into self-parody than its predecessor Tags:culturefilm reviewsinews.co.ukshowbizuconn edu
Wild Isles, BBC One, review: Attenborough's local series sits proudly along his more far-flung adventures,Sir David, still nimble and twinkling at 96, radiated warmth and curiosity as he watched puffins gather on Skomer Island in Wales Tags:cultureinews.co.ukSir David Attenboroughuconn edu
The "White Lotus" Theme Song Gets an Official Tiësto Remix,The theme song for The White Lotus season two has officially gotten a Tiësto remix, cementing the song's status as a club banger. Tags:EntertainmentMusicpopsugar.comthe white lotusTV
How Beethoven's hair reveals the legendary composer may have drunk himself to death,Ludwig van Beethoven may have drunk himself to death, say scientists who mapped his genome from a lock of the great composer's hair. Tags:AlcoholBeethovenHistorical Newsliver diseaseMusicStudy Findsstudyfinds.org
Fever Ray's Radical Romantics is a haunting exploration of love,On their third album, Fever Ray unearths a melting pot of feelings Tags:cultureinews.co.ukuconn edu
Oscars 2023 best dressed: Cara Delevingne, Rihanna and Malala – and what their red carpet outfits mean,On the champagne-coloured carpet we saw everything from knickers to maternity wear, a Marilyn moment and the perfect Hollywood comeback Tags:cultureinews.co.ukuconn edu
John Mayer Performs Taylor Swift Duet 'Half of My Heart' & Fans Are Shocked: 'First Time in Years',The song was first released at the start of the two musicians’ relationship in 2009. Tags:billboardbillboard.comcultureMusicMusic ChartsMusic Newspop
Three ways moving on from Aaron Rodgers impacts Packers
Three ways moving on from Aaron Rodgers impacts Packers,Moving on from a franchise quarterback is a challenging situation for any NFL team. Here are three ways the Packers will be impacted if Rodgers has indeed played his last game as a member of the
DOH warns vs eating seafood from oil spill areas
DOH warns vs eating seafood from oil spill areas,The Department of Health warned the public yesterday against eating fish and other seafood from areas affected by the oil spill.
The post DOH warns vs eating seafood from oil spill areas appeared first
Washington turns to Wall Street to help rescue dying bank
Washington turns to Wall Street to help rescue dying bank,In a scene reminiscent of the last financial crisis, the federal government turned to Wall Street this week for help with a blossoming emergency in the banking sector
Isn’t it ironic that Mercury, the planet closest to the Sun, has ice on its poles?,Mercury has closer encounters with the Sun than any other planet in the solar system. It seems that such a planet would be doomed to turn into another Arrakis, especially after billions of years of being scorched by radiation. Tags:iceInterviewsMercuryNewsScienceSunSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIRE
Full trailer for 'Strange New Worlds' feels like old school 'Star Trek' adventure fans know and love,It's been almost three years since we've seen Anson Mount play Captain Christopher Pike in a Star Trek series. Mount's version of the character — a figure dating back to Star Trek's original unaired pilot episode nearly 60 years ago — was a major player in the second season of Discovery, and popped up again in the Short Treks anthology series. Both those appearances came to a halt in 2019. Tags:Anson MountNewsParamountStar TrekStar Trek Strange New WorldsSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIRETrailerstv