‘This program saved my life.’ Jackson treatment court recognizes recent graduates,The number of graduates from the four-phase, year-long drug treatment program now stands at 662, officials said.
‘This program saved my life.’ Jackson treatment court recognizes recent graduates
The number of graduates from the four-phase, year-long drug treatment program now stands at 662, officials said.
CAF announces $4 billion water project financing for Latam, Caribbean,"Depending on the country and its needs we are going to see which are the projects that we're going to finance," Asinelli said ahead of the announcement, made on the sidelines of the United Nations Water Conference. He said part of the importance of investment in water and sanitation is it affects policies in other sectors including health and education. Tags:Devdiscoursedevdiscourse.comWASH
Real-time quantum error correction beyond break-even,The ambition of harnessing the quantum for computation is at odds with the fundamental phenomenon of decoherence. The purpose of quantum error correction (QEC) is to counteract the natural tendency of a complex system to decohere. This cooperative process, which requires participation of multiple quantum and classical components, creates a special type of dissipation that removes the entropy caused by the errors faster than the rate at which these errors corrupt the stored quantum information. Previous experimental attempts to engineer such a process1–7 faced the generation of an excessive number of errors that overwhelmed the error-correcting capability of the process itself. Whether it is practically possible to utilize QEC for extending quantum coherence thus remains an open question. Here we answer it by demonstrating a fully stabilized and error-corrected logical qubit whose quantum coherence is substantially longer than that of all the imperfect quantum components involved in the QEC process, beating the best of them with a coherence gain of G = 2.27 ± 0.07. We achieve this performance by combining innovations in several domains including the fabrication of superconducting quantum circuits and model-free reinforcement learning. A study demonstrates the extension of a lifetime of a quantum memory using active quantum error correction and reinforcement learning. Tags:abEickbuschhumanities and social sciencesimultidisciplinaryNaturenature.comquantum informationqubitsRoyersscienceSinghSivakTsioutsiosV. V.
Thalamus drives vocal onsets in the zebra finch courtship song,While motor cortical circuits contain information related to specific movement parameters1, long-range inputs also have a critical role in action execution2,3. Thalamic projections can shape premotor activity2–6 and have been suggested7 to mediate the selection of short, stereotyped actions comprising more complex behaviours8. However, the mechanisms by which thalamus interacts with motor cortical circuits to execute such movement sequences remain unknown. Here we find that thalamic drive engages a specific subpopulation of premotor neurons within the zebra finch song nucleus HVC (proper name) and that these inputs are critical for the progression between vocal motor elements (that is, ‘syllables’). In vivo two-photon imaging of thalamic axons in HVC showed robust song-related activity, and online perturbations of thalamic function caused song to be truncated at syllable boundaries. We used thalamic stimulation to identify a sparse set of thalamically driven neurons within HVC, representing ~15% of the premotor neurons within that network. Unexpectedly, this population of putative thalamorecipient neurons is robustly active immediately preceding syllable onset, leading to the possibility that thalamic input can initiate individual song components through selectively targeting these ‘starter cells’. Our findings highlight the motor thalamus as a director of cortical dynamics in the context of an ethologically relevant behavioural sequence. In songbird, thalamus drives a small population of premotor neurons to initiate transitions between song syllables. Tags:Ackert SmithAriadnabirdsongCorredera AsensioDevorahelmalehFelix W.humanities and social sciencesKranzLyn A.MargotmollmultidisciplinaryNaturenature.comNeural circuitsscience
Hate working weekends? Try a time tracker,The thought of time sheets in academia might fill you with horror, but they could help you to prioritize tasks, says Inger Mewburn. Tags:CareersIngerLab lifeMewburnnature.com
Ultrafast structural changes direct the first molecular events of vision,Vision is initiated by the rhodopsin family of light-sensitive G protein-coupled receptors (GPCRs)1. A photon is absorbed by the 11-cis retinal chromophore of rhodopsin, which isomerizes within 200 femtoseconds to the all-trans conformation2, thereby initiating the cellular signal transduction processes that ultimately lead to vision. However, the intramolecular mechanism by which the photoactivated retinal induces the activation events inside rhodopsin remains experimentally unclear. Here we use ultrafast time-resolved crystallography at room temperature3 to determine how an isomerized twisted all-trans retinal stores the photon energy that is required to initiate the protein conformational changes associated with the formation of the G protein-binding signalling state. The distorted retinal at a 1-ps time delay after photoactivation has pulled away from half of its numerous interactions with its binding pocket, and the excess of the photon energy is released through an anisotropic protein breathing motion in the direction of the extracellular space. Notably, the very early structural motions in the protein side chains of rhodopsin appear in regions that are involved in later stages of the conserved class A GPCR activation mechanism. Our study sheds light on the earliest stages of vision in vertebrates and points to fundamental aspects of the molecular mechanisms of agonist-mediated GPCR activation. One picosecond after photoactivation, isomerized retinal pulls away from half of its numerous interactions with its binding pocket, and the excess of the photon energy is released through an anisotropic protein breathing motion in the direction of the extracellular space. Tags:Christopher J.giorgiaGruhlhumanities and social sciencesMatthew JMilnemultidisciplinaryNaturenature.comOrtolaniPhotobiologyRodriguessciencethomasTobiasvisual systemWeinertX ray crystallography
Immunoglobulin M perception by Fc渭R,Immunoglobulin M (IgM) is the first antibody to emerge during embryonic development and the humoral immune response1. IgM can exist in several distinct forms, including monomeric, membrane-bound IgM within the B cell receptor (BCR) complex, pentameric and hexameric IgM in serum and secretory IgM on the mucosal surface. FcμR, the only IgM-specific receptor in mammals, recognizes different forms of IgM to regulate diverse immune responses2–5. However, the underlying molecular mechanisms remain unknown. Here we delineate the structural basis of the FcμR–IgM interaction by crystallography and cryo-electron microscopy. We show that two FcμR molecules interact with a Fcμ-Cμ4 dimer, suggesting that FcμR can bind to membrane-bound IgM with a 2:1 stoichiometry. Further analyses reveal that FcμR-binding sites are accessible in the context of IgM BCR. By contrast, pentameric IgM can recruit four FcμR molecules to bind on the same side and thereby facilitate the formation of an FcμR oligomer. One of these FcμR molecules occupies the binding site of the secretory component. Nevertheless, four FcμR molecules bind to the other side of secretory component-containing secretory IgM, consistent with the function of FcμR in the retrotransport of secretory IgM. These results reveal intricate mechanisms of IgM perception by FcμR. The structural basis for the molecular mechanism of recognition of different IgM forms by the IgM receptor FcμR is determined using crystallography and cryo-electron microscopy. Tags:antibodiesChenggongCryoelectron microscopyHaohumanities and social sciencesJILimultidisciplinaryNaturenature.comRuixuescienceShenwangX ray crystallographyYaxinYuxinZhang
Acceleration of 1I/鈥極umuamua from radiolytically produced H2 in H2O ice,In 2017, 1I/‘Oumuamua was identified as the first known interstellar object in the Solar System1. Although typical cometary activity tracers were not detected2–6, ‘Oumuamua showed a notable non-gravitational acceleration7. So far, there has been no explanation that can reconcile these constraints8. Owing to energetic considerations, outgassing of hyper-volatile molecules is favoured over heavier volatiles such as H2O and CO2 (ref. 9). However, there are theoretical and/or observational inconsistencies10 with existing models invoking the sublimation of pure H2 (ref. 9), N2 (ref. 11) and CO (ref. 12). Non-outgassing explanations require fine-tuned formation mechanisms and/or unrealistic progenitor production rates7,13–15. Here we report that the acceleration of ‘Oumuamua is due to the release of entrapped molecular hydrogen that formed through energetic processing of an H2O-rich icy body. In this model, ‘Oumuamua began as an icy planetesimal that was irradiated at low temperatures by cosmic rays during its interstellar journey, and experienced warming during its passage through the Solar System. This explanation is supported by a large body of experimental work showing that H2 is efficiently and generically produced from H2O ice processing, and that the entrapped H2 is released over a broad range of temperatures during annealing of the amorphous water matrix16–22. We show that this mechanism can explain many of ‘Oumuamua’s peculiar properties without fine-tuning. This provides further support3 that ‘Oumuamua originated as a planetesimal relic broadly similar to Solar System comets. Acceleration of ‘Oumuamua is due to the release of entrapped molecular hydrogen formed through energetic processing of an H2O-rich icy body, supporting the idea that it originated as a planetesimal relic similar to Solar System comets. Tags:asteroidsBergnercomets and Kuiper beltDarryl Z.humanities and social sciencesinterstellar mediumJennifer B.multidisciplinaryNaturenature.comscienceSeligman
Three ways moving on from Aaron Rodgers impacts Packers
Three ways moving on from Aaron Rodgers impacts Packers,Moving on from a franchise quarterback is a challenging situation for any NFL team. Here are three ways the Packers will be impacted if Rodgers has indeed played his last game as a member of the
DOH warns vs eating seafood from oil spill areas
DOH warns vs eating seafood from oil spill areas,The Department of Health warned the public yesterday against eating fish and other seafood from areas affected by the oil spill.
The post DOH warns vs eating seafood from oil spill areas appeared first
Washington turns to Wall Street to help rescue dying bank
Washington turns to Wall Street to help rescue dying bank,In a scene reminiscent of the last financial crisis, the federal government turned to Wall Street this week for help with a blossoming emergency in the banking sector
Birds sometimes hitch rides on ships—and it's changing the way they migrate,Freighter crews have long told stories of sparrows and nightjars, owls, and herons settling on their boats’ decks. Tags:AnimalsBirdsEnvironmentpopsci.comPopular ScienceWildlife
What we know about hormonal birth control and breast cancer risk,Don't throw out your birth control pills just yet—studies show this risk disappears eventually after stopping hormonal birth control. Tags:CancerdiseasesHealthmedicinepopsci.comPopular ScienceScience
What ancient tsunamis can teach us about future disasters,Gigantic tsunamis have been decimating coastlines since time immemorial. We ignore these prehistoric warnings at our own peril. Tags:Environmentpopsci.comPopular ScienceScienceweather
