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• Structural and mechanistic insights into fungal 尾-1,3-glucan synthase FKS1

  Structural and mechanistic insights into fungal 尾-1,3-glucan synthase FKS1,The membrane-integrated synthase FKS is involved in the biosynthesis of β-1,3-glucan, the core component of the fungal cell wall1,2. FKS is the target of widely prescribed antifungal drugs, including echinocandin and ibrexafungerp3,4. Unfortunately, the mechanism of action of FKS remains enigmatic and this has hampered development of more effective medicines targeting the enzyme. Here we present the cryo-electron microscopy structures of Saccharomyces cerevisiae FKS1 and the echinocandin-resistant mutant FKS1(S643P). These structures reveal the active site of the enzyme at the membrane–cytoplasm interface and a glucan translocation path spanning the membrane bilayer. Multiple bound lipids and notable membrane distortions are observed in the FKS1 structures, suggesting active FKS1–membrane interactions. Echinocandin-resistant mutations are clustered at a region near TM5–6 and TM8 of FKS1. The structure of FKS1(S643P) reveals altered lipid arrangements in this region, suggesting a drug-resistant mechanism of the mutant enzyme. The structures, the catalytic mechanism and the molecular insights into drug-resistant mutations of FKS1 revealed in this study advance the mechanistic understanding of fungal β-1,3-glucan biosynthesis and establish a foundation for developing new antifungal drugs by targeting FKS. Using cryo-electron microscopy, the molecular architecture and catalytic mechanism of action of the fungal β-1,3-glucan synthase FKS1 are determined. Tags: chai Changdong Cryoelectron microscopy Fungi glycobiology Hu Huanhuan humanities and social sciences Jia Liu multidisciplinary Nature nature.com ping science Sun Xinlin Yang

• JoJo Siwa Seemingly Just Called Out Nickelodeon For Hauling Her Into A Meeting With The Company’s President After She Publicly Came Out As Gay

  JoJo Siwa Seemingly Just Called Out Nickelodeon For Hauling Her Into A Meeting With The Company’s President After She Publicly Came Out As Gay,One year after JoJo came out as LGBTQ+, Nickelodeon failed to invite her to its annual Kids’ Choice Awards — despite the fact that she was nominated. Tags: breaking team BuzzFeed News buzzfeed news crossposting buzzfeed.com Celebrity JoJo Siwa uk celeb team

• GOP operative who advised Youngkin moves to pro-DeSantis PAC

  GOP operative who advised Youngkin moves to pro-DeSantis PAC,A top Republican operative who worked as an adviser on Virginia Gov. Glenn Youngkin’s winning campaign has signed on to work for a super PAC urging Florida Gov. Ron DeSantis to run for president Tags: AP cnn columbia Democratic Department of land Security Donald Trump Eric Greitens Florida Glenn Youngkin gop independent.co.uk ken cuccinelli Missouri New York Nikki Haley Pac POLITICO ted cruz Terry McAuliffe Texas Virginia

• Train strikes: Will there be more walkouts after latest March and April dates called off?

  Train strikes: Will there be more walkouts after latest March and April dates called off?,Strikes have been called off but RMT union insists the dispute continues Tags: independent.co.uk Internal Mick Lynch Rail Delivery Group Rail strikes RMT train operators train strikes

• 38 Products Your Baby Would Tell You They Want If They Could Talk

  38 Products Your Baby Would Tell You They Want If They Could Talk,These products are great for baby *and* parent. Tags: buzzfeed buzzfeed.com comtent market amazon majority market priority post shopping

• I Can’t Believe It’s Nut Butter

  I Can’t Believe It’s Nut Butter,This secret ingredient enlivens vegan cacio e pepe, creamy mattar paneer and more recipes. Tags: Content Type cooking Cooking and Cookbooks nytimes.com recipe recipes service Service Content

• Manhattan grand jury investigating Trump unlikely to decide on any possible charges this week, sources say

  Manhattan grand jury investigating Trump unlikely to decide on any possible charges this week, sources say,Any vote on a possible indictment against Trump would be pushed into next week. Tags: Alvin Bragg cbsnews.com Donald Trump Politics

• The A.I. Chatbots Have Arrived. Time to Talk to Your Kids.

  The A.I. Chatbots Have Arrived. Time to Talk to Your Kids.,Artificial intelligence can make adults nervous, but experts say exploring it as a family is the best way to understand its pros and cons. Tags: Artificial intelligence chatgpt Children Children and Childhood Computers and the Internet nytimes.com Robot Robots and Robotics search engines Tech Industry

• Volkswagen Group to build four new EVs and batteries in Spain, including upcoming ID.2

  Volkswagen Group to build four new EVs and batteries in Spain, including upcoming ID.2,According to a recent update from Volkswagen Passenger Cars CEO Thomas Schaefer, the Group intends to build at least four... Tags: cupra Electrek electrek.co Skoda Spain Volkswagen volkswagen group volkswagen id.2

• Zurich 1-9 Arsenal: Gunners go goal crazy as Frida Maanum hits a hat-trick to down the Swiss side

  Zurich 1-9 Arsenal: Gunners go goal crazy as Frida Maanum hits a hat-trick to down the Swiss side,Frida Maanum hit a hat-trick to help Arsenal thump Zurich last night and seal top spot in their Champions League group ahead of Lyon. Tags: Arsenal Champions League dailymail dailymail.co.uk Football Mail Online Sport

• Zuckerberg to fire ‘10% of Meta’s 87,000 staff’ in company’s first ever mass layoffs, says analyst

  Zuckerberg to fire '10% of Meta's 87,000 staff' in company's first ever mass layoffs, says analyst,The Facebook founder, 38, is planning 'large-scale' job losses that could total around 8,700 employees after the company's profits slumped and nearly $80billion was wiped from their value. Tags: dailymail dailymail.co.uk Elon Musk Facebook Mail Online Mark Zuckerberg Meta News

• Zopa ups easy access savings rate to 1.85%: Why the app-based bank is popular

  Zopa ups easy access savings rate to 1.85%: Why the app-based bank is popular,Zopa has raised the rate on its easy-access Smart Saver account to1.85%, making it the third most generous deal on the market. Tags: dailymail dailymail.co.uk latest Mail Online money moneysaving News Saving and Banking

• Zoopla: Home sellers forced to cut asking prices by £14,000 in order to shift properties

  Zoopla: Home sellers forced to cut asking prices by £14,000 in order to shift properties,On average sellers are accepting a 4.5% discount when they sell their home - the highest gap between asking price and sale price for five years. Tags: dailymail dailymail.co.uk Mail Online money moneymortgageshome Mortgages

• Zoopla warns of ‘double-digit’ house price drop if mortgage rates stay at 6%

  Zoopla warns of 'double-digit' house price drop if mortgage rates stay at 6%,Surging UK mortgage rates have led to a 33 per cent drop in buyer demand since the 'mini' Budget, Zoopla said. It warned prices could fall sharply if mortgage rates linger at the 6 per cent mark. Tags: dailymail dailymail.co.uk latest Mail Online money moneymortgageshome Mortgages News

• Zooey Deschanel, 42, is stylishly chic in retro-inspired jeans as she enjoys outing in Santa Monica

  Zooey Deschanel, 42, is stylishly chic in retro-inspired jeans as she enjoys outing in Santa Monica,Zooey Deschanel showcased her fashionable side as she stepped out in a retro-inspired outfit as she ran a few errands in Santa Monica and picked up her son, Charlie. Tags: dailymail dailymail.co.uk Editor's Picks Entertainment Mail Online tvshowbiz

• Zooey Deschanel cuts a casual figure in a hoodie and leggings while stepping out on a coffee run

  Zooey Deschanel cuts a casual figure in a hoodie and leggings while stepping out on a coffee run,Zooey Deschanel was spotted while stepping out for coffee in Santa Monica on Sunday morning. The 42-year-old performer appeared to be making the most of the pleasant autumn weather. Tags: dailymail dailymail.co.uk Mail Online tvshowbiz

• Zooey Deschanel cuts a casual figure in a hoodie and leggings while stepping out on a coffee run

  Zooey Deschanel cuts a casual figure in a hoodie and leggings while stepping out on a coffee run,Zooey Deschanel was spotted while stepping out for coffee in Santa Monica on Sunday morning. The 42-year-old performer appeared to be making the most of the pleasant autumn weather. Tags: dailymail dailymail.co.uk Mail Online tvshowbiz

• Zooey Deschanel cuts a casual figure in a hoodie and leggings while stepping out on a coffee run

  Zooey Deschanel cuts a casual figure in a hoodie and leggings while stepping out on a coffee run,Zooey Deschanel was spotted while stepping out for coffee in Santa Monica on Sunday morning. The 42-year-old performer appeared to be making the most of the pleasant autumn weather. Tags: dailymail dailymail.co.uk Mail Online tvshowbiz

• Zoey Deutch ‘is robbed of $300,000 worth of jewellery and cash after thieves break into her home’

  Zoey Deutch 'is robbed of $300,000 worth of jewellery and cash after thieves break into her home',According to TMZ , the actress, 27, arrived home earlier this month to discover her door smashed in and her house ransacked. Tags: dailymail dailymail.co.uk Entertainment Los Angeles Mail Online popular tvshowbiz

• Zoe Kravitz puts on leggy display in tiny denim shorts and green T-Shirt on solo stroll in New York

  Zoe Kravitz puts on leggy display in tiny denim shorts and green T-Shirt on solo stroll in New York,The 33-year-old actress showcased her stunning legs in a pair of tiny denim shorts on a solo stroll in New York City on Wednesday. Tags: dailymail dailymail.co.uk Entertainment Mail Online New York tvshowbiz Zoe Kravitz

• Zoe Kravitz dresses for fall during afternoon walk with a friend in NYC

  Zoe Kravitz dresses for fall during afternoon walk with a friend in NYC,Zoe Kravitz enjoyed a stroll with a friend in the Big Apple on Saturday. The 33-year-old daughter of Lenny Kravitz dressed for fall in a navy wool blazer over a spaghetti-strapped top Tags: dailymail dailymail.co.uk Entertainment Lenny Kravitz Mail Online popular tvshowbiz Zoe Kravitz

• Zoe Kravitz admits Big Little Lies is probably finished because of director Jean-Marc Vallee’s death

  Zoe Kravitz admits Big Little Lies is probably finished because of director Jean-Marc Vallee's death,Zoë Kravitz believes Big Little Lies is 'done.' The 33-year-old actress doubts there will be another series of the hit HBO show because late-director Jean-Marc Vallée was the 'visionary' Tags: dailymail dailymail.co.uk hbo Mail Online tiktok tvshowbiz Zoe Kravitz

• Zoe Kravitz admits Big Little Lies is probably finished because of director Jean-Marc Vallee’s death

  Zoe Kravitz admits Big Little Lies is probably finished because of director Jean-Marc Vallee's death,Zoë Kravitz believes Big Little Lies is 'done.' The 33-year-old actress doubts there will be another series of the hit HBO show because late-director Jean-Marc Vallée was the 'visionary' Tags: dailymail dailymail.co.uk hbo Mail Online tiktok tvshowbiz Zoe Kravitz

• Zoe Kazan, 39, hides her growing baby bump underneath a leopard print coat

  Zoe Kazan, 39, hides her growing baby bump underneath a leopard print coat,The actress left NBC Studios after showing off her baby bump last month at the New York Film Festival premiere of her upcoming film She Said. Tags: dailymail dailymail.co.uk Mail Online New York tvshowbiz

• Zoe Kazan, 39, hides her growing baby bump underneath a leopard print coat

  Zoe Kazan, 39, hides her growing baby bump underneath a leopard print coat,The actress left NBC Studios after showing off her baby bump last month at the New York Film Festival premiere of her upcoming film She Said. Tags: dailymail dailymail.co.uk Mail Online New York tvshowbiz

• Zoe Kazan, 39, hides her growing baby bump underneath a leopard print coat

  Zoe Kazan, 39, hides her growing baby bump underneath a leopard print coat,The actress left NBC Studios after showing off her baby bump last month at the New York Film Festival premiere of her upcoming film She Said. Tags: dailymail dailymail.co.uk Mail Online New York tvshowbiz

• Zoe Foster Blake is all smiles as she visits the set of iconic children’s TV series Play School

  Zoe Foster Blake is all smiles as she visits the set of iconic children's TV series Play School,Zoë Foster Blake could not wipe the smile off her face on Monday when she visited the set of iconic children's TV series Play School. Tags: dailymail dailymail.co.uk Entertainment Mail Online New South Wales popular tvshowbiz

• Zoe Foster Blake and husband Hamish travel with $4,000 designer luggage

  Zoe Foster Blake and husband Hamish travel with $4,000 designer luggage,Just like many other parents, Zoë Foster Blake and her husband Hamish are taking their children away during the school holidays. Tags: dailymail dailymail.co.uk Entertainment Mail Online Sydney tvshowbiz

• Zlatan Ibrahimovic slams PSG star Kylian Mbappe for trying to ‘be bigger than the club’

  Zlatan Ibrahimovic slams PSG star Kylian Mbappe for trying to 'be bigger than the club',The 23-year-old signed a three-year contract extension in May after the French champions successfully convinced him to continue his adventure in Ligue 1. Tags: AC Milan Barcelona dailymail dailymail.co.uk Editor's Picks Football Inter Milan kylian mbappe Leo Messi Ligue 1 Mail Online neymar PSG Sport Sports Zlatan Ibrahimovic

• Zizzi, TGI Fridays among UK restaurants increasing sharing dishes to combat cost of living crisis

  Zizzi, TGI Fridays among UK restaurants increasing sharing dishes to combat cost of living crisis,Zizzi, TGI Fridays among UK restaurants increasing sharing dishes to combat cost of living crisis,Big brands such as TGI Fridays, Byron Burgers and Zizzi have increased the amount of dishes designed to be shared as customers lower the amount they are spending. Tags: dailymail dailymail.co.uk latest Mail Online News

• Zion Williamson suffers fresh injury blow by rolling his ankle in preseason game

  Zion Williamson suffers fresh injury blow by rolling his ankle in preseason game,Zion Williamson's season is already off to an inauspicious start, as the hugely talented but injury prone superstar suffered a fresh injury blow Wednesday night vs. the Heat. Tags: dailymail dailymail.co.uk Mail Online NBA New Orlean Pelicans reviews Sport Sports

• Zinedine Zidane insists Karim Benzema is ‘the GREATEST striker in the history of French football’

  Zinedine Zidane insists Karim Benzema is 'the GREATEST striker in the history of French football',Zinedine Zidane has labelled Ballon d'Or winner Karim Benzema as the 'greatest striker in the history of French football'. The Real Madrid hitman claimed the 2022 Ballon d'Or award on Monday. Tags: dailymail dailymail.co.uk Editor's Picks Football Karim Benzema Kevin De Bruyne Mail Online Real Madrid Sadio Mane Sport Sports

• Zinchenko, Bajcetic, Raya: 10 things we learned from the Premier League

  Zinchenko, Bajcetic, Raya: 10 things we learned from the Premier League,Stefan Bajcetic looked composed in midfield at Anfield, Oleksandr Zinchenko showed his class in Arsenal's win over Man United and David Raya looks like a future big-six goalkeeper. Tags: Arsenal Aston Villa Bournemouth Brentford Brighton Brighton and Hove Albion Chelsea Crystal Palace dailymail dailymail.co.uk Erik ten Hag Erling Haaland Everton Football Frank Lampard Fulham Leeds United Leicester City Liverpool Mail Online Manchester City Manchester United Mikel Arteta Newcastle United nottingham forest Patrick Vieira premier league Southampton Sport Tottenham Hotspur Transfer news West Ham United Wolverhampton Wanderers

• Zillah Byng-Thorne to be replaced by US news exec Jon Steinberg at Future

  Zillah Byng-Thorne to be replaced by US news exec Jon Steinberg at Future,After a five-month search, the publishing giant behind Country Life and Marie Claire landed on the former MailOnline chief Jon Steinberg (pictured). Tags: BUSINESS dailymail dailymail.co.uk Mail Online money moneymarkets

• Zendaya shows off her new bob haircut in stunning new social media post

  Zendaya shows off her new bob haircut in stunning new social media post,Zendaya showed off her new bob haircut in a stunning social media post on Wednesday. Tags: dailymail dailymail.co.uk Mail Online tvshowbiz Zendaya

• Zen your way to a healthy heart: Trendy mindfulness lowers blood pressure

  Zen your way to a healthy heart: Trendy mindfulness lowers blood pressure,Mindfulness practice that quiets the mind and body is an effective way to tamp down high blood pressure, according to Brown University researchers. Tags: dailymail dailymail.co.uk Health Mail Online popular The Science

• Zelensky looks far from enthusiastic as Macron offers hug in Kyiv

  Zelensky looks far from enthusiastic as Macron offers hug in Kyiv,Zelensky looked as though he'd rather be in the trenches of Severodonetsk when Macron, dressed in his trademark navy suit, wrapped a crisply-laundered sleeve around his torso Tags: dailymail dailymail.co.uk Emmanuel Macron Mail Online News Vladimir Putin Volodymyr Zelensky War crimes

• Zelensky and Zuckerberg set appear alongside disgraced FTX founder Sam Bankman-Fried

  Zelensky and Zuckerberg set appear alongside disgraced FTX founder Sam Bankman-Fried,Disgraced FTX founder Sam Bankman-Fried will still appear at a New York Times event alongside world leaders and business magnates despite the collapse of his company. Tags: Ben Affleck dailymail dailymail.co.uk Mail Online Mark Zuckerberg Mike Pence News Volodymyr Zelensky

• Zelensky and Zuckerberg set appear alongside disgraced FTX founder Sam Bankman-Fried

  Zelensky and Zuckerberg set appear alongside disgraced FTX founder Sam Bankman-Fried,Disgraced FTX founder Sam Bankman-Fried will still appear at a New York Times event alongside world leaders and business magnates despite the collapse of his company. Tags: Ben Affleck dailymail dailymail.co.uk Mail Online Mark Zuckerberg Mike Pence News Volodymyr Zelensky

• Zelensky and Zuckerberg set appear alongside disgraced FTX founder Sam Bankman-Fried

  Zelensky and Zuckerberg set appear alongside disgraced FTX founder Sam Bankman-Fried,Disgraced FTX founder Sam Bankman-Fried will still appear at a New York Times event alongside world leaders and business magnates despite the collapse of his company. Tags: Ben Affleck dailymail dailymail.co.uk Mail Online Mark Zuckerberg Mike Pence News Volodymyr Zelensky
• Pat McAfee reveals if he knows what Packers’ Aaron Rodgers will do in 2023
  Pat McAfee reveals if he knows what Packers' Aaron Rodgers will do in 2023,There are multiple reasons fans would assume Rodgers would give McAfee some inside information. But does McAfee actually know Rodgers' plans?
• Denny Hamlin Goes Against Jeff Gordon as He Reveals What Hendrick Motorsports Were “Messing With”
  Denny Hamlin Goes Against Jeff Gordon as He Reveals What Hendrick Motorsports Were “Messing With”,Denny Hamlin discusses why he feels Hendrick Motorsports might actually be in trouble with respect to their recently confiscated parts.
• Three ways moving on from Aaron Rodgers impacts Packers
  Three ways moving on from Aaron Rodgers impacts Packers,Moving on from a franchise quarterback is a challenging situation for any NFL team. Here are three ways the Packers will be impacted if Rodgers has indeed played his last game as a member of the
• DOH warns vs eating seafood from oil spill areas
  DOH warns vs eating seafood from oil spill areas,The Department of Health warned the public yesterday against eating fish and other seafood from areas affected by the oil spill. The post DOH warns vs eating seafood from oil spill areas appeared first
• Inside ‘world’s best airport’ with trampolines, waterfalls and a huge indoor jungle
  Inside 'world’s best airport' with trampolines, waterfalls and a huge indoor jungle,The world's coolest airport has officially been named and it offers a completely unique customer experience with an indoor rainforest and the tallest slide in an
• ‘Smile’ viral marketing campaign freaked out MLB fans with creepy grins in the stands
  ‘Smile’ viral marketing campaign freaked out MLB fans with creepy grins in the stands,Getting paid to smile doesn’t sound like such a bad gig, eh? We guess it’s not — until you read the fine print and learn you’ve gotta do it in the most public of pl
• Jason Reitman Made Sure Ernie Hudson’s Winston Gets His Due In Ghostbusters: Afterlife 2 – Exclusive
  Jason Reitman Made Sure Ernie Hudson's Winston Gets His Due In Ghostbusters: Afterlife 2 - Exclusive,Ernie Hudson shared that Winston will get the respect he deserves in "Ghostbusters: Afterlife 2," according to his conversation with direct
• Washington turns to Wall Street to help rescue dying bank
  Washington turns to Wall Street to help rescue dying bank,In a scene reminiscent of the last financial crisis, the federal government turned to Wall Street this week for help with a blossoming emergency in the banking sector

• ‘Jurassic Park’ fans can thank Steven Spielberg for Alan Grant’s accent in the original film

  'Jurassic Park' fans can thank Steven Spielberg for Alan Grant's accent in the original film,There is no denying that 1993's Jurassic Park is a near-perfect movie. If you really wanted to start picking apart the scant flaws of the Steven Spielberg classic, you may be inclined to mention Sam Neill's line delivery as Alan Grant. Tags: Jurassic Park Jurassic World Dominion Movies News Sam Neill Steven Spielberg SYFY Official Site SYFY WIRE Blog Post syfy.com SYFYWIRE

• Is that the Force? Enormous laser beam shoots through a galaxy far, far away

  Is that the Force? Enormous laser beam shoots through a galaxy far, far away,Darth Vader would be jealous, but so would Luke Skywalker and Han Solo. Both the Rebels and the Imperial Forces only wish they had this laser (which could easily vaporize Luke’s X-wing, blast the Millennium Falcon or take down the Death Star) in their arsenal. Tags: colliding galaxies Force Interviews News Science Space Lasers SYFY Official Site SYFY WIRE Blog Post syfy.com SYFYWIRE

• ‘Resident Alien’: Alice Wetterlund’s goal on set is to get one good laugh out of showrunner Chris Sheridan

  'Resident Alien': Alice Wetterlund's goal on set is to get one good laugh out of showrunner Chris Sheridan,It's a good day on the set of SYFY's Resident Alien if you can get a hearty laugh out of showrunner/executive producer Chris Sheridan. Tags: Alice Wetterlund News Resident Alien Sci Fi SYFY SYFY Official Site SYFY WIRE Blog Post syfy.com SYFYWIRE Television tv

• From ‘Spider-Man’ to ‘Avengers’: The 19 best movies to kick off the last 20 years of summer blockbusters

  From 'Spider-Man' to 'Avengers': The 19 best movies to kick off the last 20 years of summer blockbusters,You think the superhero craze in Hollywood is anything new? The summer moviegoing season has — for the most part — been defined by the comic book genre for two solid decades. Tags: blockbusters Fantasy Features Lists Movies Science Fiction Summer Movies SYFY Official Site SYFY WIRE Blog Post syfy.com SYFYWIRE

• Sharon Stone set to join DC’s ‘Blue Beetle’ as new villain Victoria Kord

  Sharon Stone set to join DC’s 'Blue Beetle' as new villain Victoria Kord,Sharon Stone is heading to the DC universe once again. Today, The Wrap broke the news that Sharon Stone is joining the Blue Beetle feature as a new villain called Victoria Kord. We also found out that ​​Raoul Max Trujillo (Mayans M.C.) has joined the cast as Carapax the Indestructible Man. Tags: Blue Beetle casting DC Movies News SYFY Official Site SYFY WIRE Blog Post syfy.com SYFYWIRE warner bros Xolo Maridueña

• Marvel sequels, ‘Jurassic World’ & ‘Nope’ lead Fandango’s most-anticipated summer 2022 movies

  Marvel sequels, 'Jurassic World' & 'Nope' lead Fandango's most-anticipated summer 2022 movies,For the first time in three years, we're looking ahead at a proper summer movie season. As much of the world continues to adapt to the ongoing COVID-19 pandemic through vaccines and other medicines, it's much easier than it was in 2020 or 2021 to feel good about going out to a theater, and that means for the first time since 2019 we've got a full lineup of major film releases headed our way throughout the hottest months of the year. Tags: Doctor Strange in the Multiverse of Madness Fandango Horror Jurassic World Dominion Movies News Sci Fi SYFY Official Site SYFY WIRE Blog Post syfy.com SYFYWIRE Thor Love and Thunder

• Original ‘Jurassic Park’ stars wanted to ‘make it matter’ with ‘Jurassic World Dominion’ return

  Original 'Jurassic Park' stars wanted to 'make it matter' with 'Jurassic World Dominion' return,Reunions, uh, find a way. Alan Grant (Sam Neill), Ellie Sattler (Laura Dern), and Ian Malcolm (Jeff Goldblum) — the original survivors of 1993's Jurassic Park — are finally coming back together under one prehistoric roof in Jurassic World Dominion later this year. Tags: Colin Trevorrow Jeff Goldblum Jurassic Park Jurassic World Dominion Laura Dern Movies News Sam Neill SYFY Official Site SYFY WIRE Blog Post syfy.com SYFYWIRE