Public say double-digit pay demands for striking rail workers should be rejected,THE public think union bosses’ double-digit pay demands for striking rail workers should be rejected, a poll has found. Fifty-two per cent say a double-digit rise is “unreasonable” while 57 per cen…
Public say double-digit pay demands for striking rail workers should be rejected
THE public think union bosses’ double-digit pay demands for striking rail workers should be rejected, a poll has found. Fifty-two per cent say a double-digit rise is “unreasonable” while 57 per cen…
Neckties, long shunned in Iran as a "sign of Westernization," are making a timid comeback,While wearing one will still "definitely turn a few heads," Iranians say ties are becoming more common after decades as a taboo accessory. Tags:cbsnews.comFashionIranIslamWORLD
RHOJ controls EMT-associated resistance to chemotherapy,The resistance of cancer cells to therapy is responsible for the death of most patients with cancer1. Epithelial-to-mesenchymal transition (EMT) has been associated with resistance to therapy in different cancer cells2,3. However, the mechanisms by which EMT mediates resistance to therapy remain poorly understood. Here, using a mouse model of skin squamous cell carcinoma undergoing spontaneous EMT during tumorigenesis, we found that EMT tumour cells are highly resistant to a wide range of anti-cancer therapies both in vivo and in vitro. Using gain and loss of function studies in vitro and in vivo, we found that RHOJ—a small GTPase that is preferentially expressed in EMT cancer cells—controls resistance to therapy. Using genome-wide transcriptomic and proteomic profiling, we found that RHOJ regulates EMT-associated resistance to chemotherapy by enhancing the response to replicative stress and activating the DNA-damage response, enabling tumour cells to rapidly repair DNA lesions induced by chemotherapy. RHOJ interacts with proteins that regulate nuclear actin, and inhibition of actin polymerization sensitizes EMT tumour cells to chemotherapy-induced cell death in a RHOJ-dependent manner. Together, our study uncovers the role and the mechanisms through which RHOJ acts as a key regulator of EMT-associated resistance to chemotherapy. RHOJ regulates epithelial-to-mesenchymal-transition-associated resistance to chemotherapy by enhancing the response to replicative stress and activating the DNA damage response, enabling tumour cells to rapidly repair DNA lesions induced by chemotherapy. Tags:BlondeauCancer therapeutic resistanceDebaugnieshumanities and social sciencesjeremyManuelMarie AstridMaudmultidisciplinaryNaturenature.comparentRodr&237;guez AcebessarascienceTumour heterogeneityZocco
In hush money scandal, Republicans need to start pacing themselves,Jim Jordan's hysterical intervention in Donald Trump's hush money scandal is a timely reminder: The GOP really needs to start pacing itself. Tags:MSNBCmsnbc.com
Mario Day 2023: Switch game deals, console bundle, collectibles, LEGO, and more,Mario Day 2023, or MAR10, has officially arrived with deals on Switch games, a new console bundle, collectibles, LEGO, and more! Tags:9to5Toys9to5toys.comApps GamesNewsNintendo
Hate working weekends? Try a time tracker,The thought of time sheets in academia might fill you with horror, but they could help you to prioritize tasks, says Inger Mewburn. Tags:CareersIngerLab lifeMewburnnature.com
Three ways moving on from Aaron Rodgers impacts Packers
Three ways moving on from Aaron Rodgers impacts Packers,Moving on from a franchise quarterback is a challenging situation for any NFL team. Here are three ways the Packers will be impacted if Rodgers has indeed played his last game as a member of the
DOH warns vs eating seafood from oil spill areas
DOH warns vs eating seafood from oil spill areas,The Department of Health warned the public yesterday against eating fish and other seafood from areas affected by the oil spill.
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Washington turns to Wall Street to help rescue dying bank
Washington turns to Wall Street to help rescue dying bank,In a scene reminiscent of the last financial crisis, the federal government turned to Wall Street this week for help with a blossoming emergency in the banking sector
Is that the Force? Enormous laser beam shoots through a galaxy far, far away,Darth Vader would be jealous, but so would Luke Skywalker and Han Solo. Both the Rebels and the Imperial Forces only wish they had this laser (which could easily vaporize Luke’s X-wing, blast the Millennium Falcon or take down the Death Star) in their arsenal. Tags:colliding galaxiesForceInterviewsNewsScienceSpace LasersSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIRE
Sharon Stone set to join DC’s 'Blue Beetle' as new villain Victoria Kord,Sharon Stone is heading to the DC universe once again. Today, The Wrap broke the news that Sharon Stone is joining the Blue Beetle feature as a new villain called Victoria Kord. We also found out that Raoul Max Trujillo (Mayans M.C.) has joined the cast as Carapax the Indestructible Man. Tags:Blue BeetlecastingDCMoviesNewsSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIREwarner brosXolo Maridueña
Marvel sequels, 'Jurassic World' & 'Nope' lead Fandango's most-anticipated summer 2022 movies,For the first time in three years, we're looking ahead at a proper summer movie season. As much of the world continues to adapt to the ongoing COVID-19 pandemic through vaccines and other medicines, it's much easier than it was in 2020 or 2021 to feel good about going out to a theater, and that means for the first time since 2019 we've got a full lineup of major film releases headed our way throughout the hottest months of the year. Tags:Doctor Strange in the Multiverse of MadnessFandangoHorrorJurassic World DominionMoviesNewsSci FiSYFY Official SiteSYFY WIRE Blog Postsyfy.comSYFYWIREThor Love and Thunder
:quality(70)/cloudfront-eu-central-1.images.arcpublishing.com/thenational/WNI4LLVXTFRKLMVOCVAPDCP4WM.jpg "Boris Johnson is unserious and insincere – he has no place in UK politics")
