The events of the Tudor dynasty have enthralled the public for centuries, none so more than the dominating reign of Henry VIII. The titan figure, who ruled England for 37 years, is known most for breaking the country from the Catholic Church and for his s...
When Henry VIII passed away in 1547 at age 55, he left behind a few children and a famously bloodstained history of failed marriages. To be fair, not all six of his couplings culminated in calamity. He stayed close friends with Anne of Cleves, for example...
The reign of Henry VIII is one of the most romanticized periods in history. Full of religious upheaval, murder, mayhem and larger-than-life figures, there are plenty of myths and misconceptions that have taken the place of real history when it comes to He...
HISTORYWant to Work Out Like Walt Whitman or Henry VIII? Try These Historic Fitness RegimensTravel through time by lifting like passengers on the Titanic or swimming like the sixth U.S. presidentThis is how you really sweat to the oldies.Bettmann/Getty Im...
King Henry VIII is probably the best-known English ruler of all time. The subject of countless stories, TV programs, and movies, Henry VIII is most famous for being hugely fat, having a fixation with beheadings, and for having no fewer than six wives duri...
HISTORYWant to Work Out Like Walt Whitman or Henry VIII? Try These Historic Fitness RegimesTravel through time by lifting like passengers on the Titanic or swimming like the sixth U.S. presidentThis is how you really sweat to the oldies.Bettmann/Getty Ima...
Many plays, films, and TV shows have explored the life and loves of Henry VIII, King of England and Ireland, who was born on June 28, 1491. But despite his place in history books and pop culture, there are likely a number of things most people don't k...
After 437 years on the sea bottom, about half of the Mary Rose's hull is now on display in Portsmouth in the U.K.(Image credit: Mary Rose Museum/Photo by Johnny Black)Powerful X-rays have revealed what's eating the wreck of King Henry VIII'...
After 437 years on the sea bottom, about half of the Mary Rose's hull is now on display in Portsmouth in the U.K.(Image credit: Mary Rose Museum/Photo by Johnny Black)Powerful X-rays have revealed what's eating the wreck of King Henry VIII'...
After 437 years on the sea bottom, about half of the Mary Rose's hull is now on display in Portsmouth in the U.K.(Image credit: Mary Rose Museum/Photo by Johnny Black)Powerful X-rays have revealed what's eating the wreck of King Henry VIII'...
After 437 years on the sea bottom, about half of the Mary Rose's hull is now on display in Portsmouth in the U.K.(Image credit: Mary Rose Museum/Photo by Johnny Black)Powerful X-rays have revealed what's eating the wreck of King Henry VIII'...
After 437 years on the sea bottom, about half of the Mary Rose's hull is now on display in Portsmouth in the U.K.(Image credit: Mary Rose Museum/Photo by Johnny Black)Powerful X-rays have revealed what's eating the wreck of King Henry VIII'...
Left to right: Abby Mueller (Jane Seymour), Samantha Pauly (Katherine Howard), Adrianna Hicks (Catherine of Aragon), Andrea Macasaet (Anne Boleyn), Brittney Mack (Anna of Cleves),Anna Uzele (Catherine Parr), in the new musical Six.I first wrote this...
The Family of Henry VIII: An Allegory of the Tudor Succession (circa 1572).Lucas de Heere, Wikimedia Commons // Public DomainThe events of the Tudor dynasty have enthralled the public for centuries, none so more than the dominating reign of Henry VII...
The Family of Henry VIII: An Allegory of the Tudor Succession (circa 1572).Lucas de Heere, Wikimedia Commons // Public DomainThe events of the Tudor dynasty have enthralled the public for centuries, none so more than the dominating reign of Henry VII...
The Family of Henry VIII: An Allegory of the Tudor Succession (circa 1572).Lucas de Heere, Wikimedia Commons // Public DomainThe events of the Tudor dynasty have enthralled the public for centuries, none so more than the dominating reign of Henry VII...
Wikimedia Commons // Public DomainAlmost 500 years after the fact, citizens of Ireland are finally allowed to freely criticize the marriage between Henry VIII and Anne Boleyn.In 1533, citizens were probably plenty angry about the union. After all, He...
Wikimedia Commons // Public DomainAlmost 500 years after the fact, citizens of Ireland are finally allowed to freely criticize the marriage between Henry VIII and Anne Boleyn.In 1533, citizens were probably plenty angry about the union. After all, He...
Getty Images Between beheading two of his six wives, sentencing hundreds of his subjects to death, and breaking his country away from the Catholic Church, is it any wonder that people today think Henry VIII was kind of, well, the worst?A trade group...
Getty ImagesBetween beheading two of his six wives, sentencing hundreds of his subjects to death, and breaking his country away from the Catholic Church, is it any wonder that people today think Henry VIII was kind of, well, the worst?A trade group o...
Measuring the knot of non-Hermitian degeneracies and non-commuting braids
Any system of coupled oscillators may be characterized by its spectrum of resonance frequencies (or eigenfrequencies), which can be tuned by varying the system’s parameters. The relationship between control parameters and the eigenfrequency spectrum is central to a range of applications1–3. However, fundamental aspects of this relationship remain poorly understood. For example, if the controls are varied along a path that returns to its starting point (that is, around a ‘loop’), the system’s spectrum must return to itself. In systems that are Hermitian (that is, lossless and reciprocal), this process is trivial and each resonance frequency returns to its original value. However, in non-Hermitian systems, where the eigenfrequencies are complex, the spectrum may return to itself in a topologically non-trivial manner, a phenomenon known as spectral flow. The spectral flow is determined by how the control loop encircles degeneracies, and this relationship is well understood for $$N=2$$ (where $$N$$ is the number of oscillators in the system)4,5. Here we extend this description to arbitrary $$N$$ . We show that control loops generically produce braids of eigenfrequencies, and for $$N > 2$$ these braids form a non-Abelian group that reflects the non-trivial geometry of the space of degeneracies. We demonstrate these features experimentally for $$N=3$$ using a cavity optomechanical system. Control loops generically produce braids of eigenfrequencies, and these braids form a non-Abelian group that reflects the non-trivial geometry of the space of degeneracies; these features are demonstrated experimentally using a cavity optomechanical system.
Structure of Tetrahymena telomerase-bound CST with polymerase 伪-primase
Telomeres are the physical ends of linear chromosomes. They are composed of short repeating sequences (such as TTGGGG in the G-strand for Tetrahymena thermophila) of double-stranded DNA with a single-strand 3′ overhang of the G-strand and, in humans, the six shelterin proteins: TPP1, POT1, TRF1, TRF2, RAP1 and TIN21,2. TPP1 and POT1 associate with the 3′ overhang, with POT1 binding the G-strand3 and TPP1 (in complex with TIN24) recruiting telomerase via interaction with telomerase reverse transcriptase5 (TERT). The telomere DNA ends are replicated and maintained by telomerase6, for the G-strand, and subsequently DNA polymerase α–primase7,8 (PolαPrim), for the C-strand9. PolαPrim activity is stimulated by the heterotrimeric complex CTC1–STN1–TEN110–12 (CST), but the structural basis of the recruitment of PolαPrim and CST to telomere ends remains unknown. Here we report cryo-electron microscopy (cryo-EM) structures of Tetrahymena CST in the context of the telomerase holoenzyme, in both the absence and the presence of PolαPrim, and of PolαPrim alone. Tetrahymena Ctc1 binds telomerase subunit p50, a TPP1 orthologue, on a flexible Ctc1 binding motif revealed by cryo-EM and NMR spectroscopy. The PolαPrim polymerase subunit POLA1 binds Ctc1 and Stn1, and its interface with Ctc1 forms an entry port for G-strand DNA to the POLA1 active site. We thus provide a snapshot of four key components that are required for telomeric DNA synthesis in a single active complex—telomerase-core ribonucleoprotein, p50, CST and PolαPrim—that provides insights into the recruitment of CST and PolαPrim and the handoff between G-strand and C-strand synthesis. Cryo-electron microscopy structures of Tetrahymena thermophila telomerase-bound Ctc1–Stn1–Ten1 and DNA polymerase α–primase provide insights into the molecular mechanisms underlying telomere replication and maintenance.
Measuring the knot of non-Hermitian degeneracies and non-commuting braids
Any system of coupled oscillators may be characterized by its spectrum of resonance frequencies (or eigenfrequencies), which can be tuned by varying the system’s parameters. The relationship between control parameters and the eigenfrequency spectrum is central to a range of applications1–3. However, fundamental aspects of this relationship remain poorly understood. For example, if the controls are varied along a path that returns to its starting point (that is, around a ‘loop’), the system’s spectrum must return to itself. In systems that are Hermitian (that is, lossless and reciprocal), this process is trivial and each resonance frequency returns to its original value. However, in non-Hermitian systems, where the eigenfrequencies are complex, the spectrum may return to itself in a topologically non-trivial manner, a phenomenon known as spectral flow. The spectral flow is determined by how the control loop encircles degeneracies, and this relationship is well understood for $$N=2$$ (where $$N$$ is the number of oscillators in the system)4,5. Here we extend this description to arbitrary $$N$$ . We show that control loops generically produce braids of eigenfrequencies, and for $$N > 2$$ these braids form a non-Abelian group that reflects the non-trivial geometry of the space of degeneracies. We demonstrate these features experimentally for $$N=3$$ using a cavity optomechanical system. Control loops generically produce braids of eigenfrequencies, and these braids form a non-Abelian group that reflects the non-trivial geometry of the space of degeneracies; these features are demonstrated experimentally using a cavity optomechanical system.
HBO cancels 'The Time Traveler's Wife' after one season
The six-part drama, written and executive produced by Moffat, told the tale of Clare and Henry and a marriage with a problem time travel.Though HBO will not be moving forward with a second season of The Time Travelers Wife, it was our privilege to partner with master storytellers Steven Moffat and David Nutter.
‘The Prom’ National Tour Stars Kaden Kearney & Kalyn West Are a Real-Life Couple!
‘The Prom’ National Tour Stars Kaden Kearney & Kalyn West Are a Real-Life Couple! The Tony-nominated musical The Prom is now playing in Los Angeles and we learned some adorable news about the show's two leads after catching the opening night…
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